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557525 Sigma-AldrichRo-32-0432 - CAS 145333-02-4 - Calbiochem

A selective cell-permeable protein kinase C inhibitor.

Ro-32-0432 - CAS 145333-02-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: 2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride

Primary Target: PKCα

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
145333-02-4	C₂₈H₂₈N₄O₂ · HCl

价格及供货情况

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Description
Overview	A selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKC_α (IC₅₀ = 9 nM) and 4-fold greater selectivity for PKC_βI (IC₅₀ = 28 nM) over PKC_ε (IC₅₀ = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	557525
Brand Family	Calbiochem®
Synonyms	2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride

References
References	Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

Product Information
CAS number	145333-02-4
ATP Competitive	N
Form	Red solid
Hill Formula	C₂₈H₂₈N₄O₂ · HCl
Chemical formula	C₂₈H₂₈N₄O₂ · HCl
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PKCα
Primary Target IC<sub>50</sub>	9 nM, 28 nM, 108 nM, against PKCα, PKCβI, and PKCε, respectively
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
557525-1MGCN	04055977193008

Documentation

Ro-32-0432 - CAS 145333-02-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Ro-32-0432 - CAS 145333-02-4 - Calbiochem 分析证书

标题	批号
557525	输入批号

参考

参考信息概述
Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

引用

标题

Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	22-October-2014 JSW
Synonyms	2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
Description	A selective cell-permeable protein kinase C inhibitor. Displays about a 10-fold greater selectivity for PKC_α (IC₅₀ = 9 nM) and a 4-fold greater selectivity for PKC_βI (IC₅₀ = 28 nM) over PKC_ε (IC₅₀ = 108 nM). Also prevents T-cell driven chronic inflammatory responses in vivo.
Form	Red solid
CAS number	145333-02-4
Chemical formula	C₂₈H₂₈N₄O₂ · HCl
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity	Standard Handling
References	Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
Citation	Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors

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