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557514 Sigma-AldrichRo-31-8425 - CAS 131848-97-0 - Calbiochem

A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC₅₀ = 15 nM for rat brain PKC).

Ro-31-8425 - CAS 131848-97-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl

Primary Target: PKC

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
131848-97-0	C₂₆H₂₄N₄O₂ · HCl

价格及供货情况

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Description
Overview	A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC₅₀ = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC₅₀ = 8 nM for PKC_α, 8 nM for PKC_βI, 14 nM for PKC_βII, 13 nM for PKC_γ, and 39 nM for PKC_ε). Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
Catalogue Number	557514
Brand Family	Calbiochem®
Synonyms	2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl

References
References	Levy, O., et al. 2015. Cell Reports 10, In press. Merritt, J.E., et al. 1997. Cell Signal 9, 53. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

Product Information
CAS number	131848-97-0
ATP Competitive	Y
Form	Red to orange-red solid
Hill Formula	C₂₆H₂₄N₄O₂ · HCl
Chemical formula	C₂₆H₂₄N₄O₂ · HCl
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PKC
Primary Target IC<sub>50</sub>	15 nM for rat brain PKC; 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε
Purity	≥94% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
557514-1MGCN	04055977192971

Documentation

Ro-31-8425 - CAS 131848-97-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Ro-31-8425 - CAS 131848-97-0 - Calbiochem 分析证书

标题	批号
557514	输入批号

参考

参考信息概述
Levy, O., et al. 2015. Cell Reports 10, In press. Merritt, J.E., et al. 1997. Cell Signal 9, 53. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	22-May-2018 JSW
Synonyms	2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
Description	A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC₅₀ = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC₅₀ = 8 nM for PKC_α, 8 nM for PKC_βI, 14 nM for PKC_βII, 13 nM for PKC_γ, and 39 nM for PKC_ε). Shows slight selectivity for the conventional PKC isozymes PKC_α, PKC_β, and PKC_γ over the Ca²⁺-independent PKC isozyme PKC_ε. Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
Form	Red to orange-red solid
CAS number	131848-97-0
Chemical formula	C₂₆H₂₄N₄O₂ · HCl
Structure formula
Purity	≥94% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Levy, O., et al. 2015. Cell Reports 10, In press. Merritt, J.E., et al. 1997. Cell Signal 9, 53. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors

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