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555558 Sigma-AldrichRho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem

The Rho/SRF Pathway Inhibitor, CCG-1423, also referenced under CAS 285986-88-1, controls the biological activity of Rho/SRF. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
285986-88-1	C₁₈H₁₃ClF₆N₂O₃

价格及供货情况

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Description
Overview	A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα_12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC₅₀ ≤300 nM) and block RhoC/ Gα₁₂-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a K_i of 1.5 µM.
Catalogue Number	555558
Brand Family	Calbiochem®
Synonyms	N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I

References
References	Lundquist, M.R., et al. 2014. Cell 156, 563.. Evelyn, C.R., et al. 2007. Mol. Cancer Ther. 6, 2249.

Product Information
CAS number	285986-88-1
Form	White solid
Hill Formula	C₁₈H₁₃ClF₆N₂O₃
Chemical formula	C₁₈H₁₃ClF₆N₂O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
555558-25MGCN	04055977268478

Documentation

Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem 分析证书

标题	批号
555558	输入批号

参考

参考信息概述
Lundquist, M.R., et al. 2014. Cell 156, 563.. Evelyn, C.R., et al. 2007. Mol. Cancer Ther. 6, 2249.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-January-2014 JSW
Synonyms	N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I
Description	A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα_12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC₅₀ ≤300 nM) and block RhoC/ Gα₁₂-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a K_i of 1.5 µM.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	285986-88-1
Chemical formula	C₁₈H₁₃ClF₆N₂O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Lundquist, M.R., et al. 2014. Cell 156, 563.. Evelyn, C.R., et al. 2007. Mol. Cancer Ther. 6, 2249.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Rho Kinase (ROCK) Inhibitors

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