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531084 Sigma-AldrichRetromer Chaperone, R55 - CAS 2076-91-7 - Calbiochem

A cell-permeable pharmacological chaperone to increase neuronal retromer levels. Improves Vps35-Vps29-Vps26 retromer complex stability.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
技术信息
Data Sheet

同义词: Thiophene-2,5-diylbis(methylene) dicarbamimidothioate, HCl, Retromer Pharmacological Chaperone, R55

Primary Target: vacuolar protein sorting (Vps) proteins

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
2076-91-7	C₈H₁₂N₄S₃ • HCl

价格及供货情况

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Description
Overview	A cell-permeable, non-toxic thienyl bis-isothiourea derived compound that acts as a pharmacological chaperone to increase neuronal retromer levels and improve the stability of trimeric Vps35-Vps29-Vps26 retromer complex. Shown to significantly increase the level of Vsp35 (EC₅₀ = 3.3 µM) and Vsp29 in hippocampal neurons. Binds at the interface between Vps35 and Vps29 (K_d = 5 µM) and interacts with side chains from both proteins. However, it does not affect the thermal unfolding of individual proteins and has no effect on mRNA levels of Vps35 and Vsp29. Shown to reduce the endogenous levels of both Aβ40 and Aβ42 and is also effective in reducing human Aβ40 and -42 levels in J20 transgenic murine model of AD36 (IC₅₀ ~ 12 µM). Also reduces the levels of both endogenous β-CTF and sAPPβ and increases the level of sAPPα in the medium. Displays a partial stabilizing effect on Vps35 even in the context of Vps29 knockdown. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	531084
Brand Family	Calbiochem®
Synonyms	Thiophene-2,5-diylbis(methylene) dicarbamimidothioate, HCl, Retromer Pharmacological Chaperone, R55

References
References	Mecozzi, V.J., et al. 2014. Nat. Chem. Biol. 10, 443.

Product Information
CAS number	2076-91-7
Form	Off-white powder
Hill Formula	C₈H₁₂N₄S₃ • HCl
Chemical formula	C₈H₁₂N₄S₃ • HCl
Hygroscopic	Hygroscopic
Reversible	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	vacuolar protein sorting (Vps) proteins
Purity	≥92% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.31084.0001	04055977242584

Documentation

Retromer Chaperone, R55 - CAS 2076-91-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Retromer Chaperone, R55 - CAS 2076-91-7 - Calbiochem 分析证书

标题	批号
531084	输入批号

参考

参考信息概述
Mecozzi, V.J., et al. 2014. Nat. Chem. Biol. 10, 443.

小册子

标题
NPI Flyer- Epigenetics and Nuclear Function Feature
Neuroscience Solutions for productive research
New Products - Antibodies, Small Molecule, Inhibitors

技术信息

标题
White Paper: Further considerations of antibody validation and usage.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-September-2014 JSW
Synonyms	Thiophene-2,5-diylbis(methylene) dicarbamimidothioate, HCl, Retromer Pharmacological Chaperone, R55
Description	A cell-permeable, non-toxic thienyl bis-isothiourea derived compound that acts as a pharmacological chaperone to increase neuronal retromer levels and improve the stability of trimeric Vps35-Vps29-Vps26 retromer complex. Shown to significantly increase the level of Vsp35 (EC₅₀ = 3.3 µM) and Vsp29 in hippocampal neurons. Binds at the interface between Vps35 and Vps29 (K_d = 5 µM) and interacts with side chains from both proteins. However, it does not affect the thermal unfolding of individual proteins and has no effect on mRNA levels of Vps35 and Vsp29. Shown to reduce the endogenous levels of both Aβ40 and Aβ42 and is also effective in reducing human Aβ40 and -42 levels in J20 transgenic murine model of AD36 (IC₅₀ ~ 12 µM). Also reduces the levels of both endogenous β-CTF and sAPPβ and increases the level of sAPPα in the medium. Displays a partial stabilizing effect on Vps35 even in the context of Vps29 knockdown.
Form	Off-white powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	2076-91-7
Chemical formula	C₈H₁₂N₄S₃ • HCl
Purity	≥92% by HPLC
Solubility	H₂O (50 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Mecozzi, V.J., et al. 2014. Nat. Chem. Biol. 10, 443.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals

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