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553509 Sigma-AldrichRas/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

Ras/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline

Primary Target: Ras/Rac

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
171927-40-5	C₁₆H₂₀N₄O₃

价格及供货情况

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Description
Overview	A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a K_d of 49 nM and inhibit its catalytic activity (IC₅₀ for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
Catalogue Number	553509
Brand Family	Calbiochem®
Synonyms	6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline

References
References	Huber, K. V. M., et al. 2014. Nature In press. He, H., et al. 1998. Mol. Cell. Biol. 18, 3829. Walsh, A.B., et al. 1997. Oncogene 15, 2553. Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.

Product Information
CAS number	171927-40-5
ATP Competitive	N
Form	Light-yellow solid
Hill Formula	C₁₆H₂₀N₄O₃
Chemical formula	C₁₆H₂₀N₄O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Ras/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.

Biological Information
Primary Target	Ras/Rac
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
553509-10MGCN	04055977193688

Documentation

Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem 分析证书

标题	批号
553509	输入批号

参考

参考信息概述
Huber, K. V. M., et al. 2014. Nature In press. He, H., et al. 1998. Mol. Cell. Biol. 18, 3829. Walsh, A.B., et al. 1997. Oncogene 15, 2553. Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-April-2014 JSW
Synonyms	6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
Description	A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a K_d of 49 nM and inhibit its catalytic activity (IC₅₀ for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
Form	Light-yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	171927-40-5
Chemical formula	C₁₆H₂₀N₄O₃
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (20 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Huber, K. V. M., et al. 2014. Nature In press. He, H., et al. 1998. Mol. Cell. Biol. 18, 3829. Walsh, A.B., et al. 1997. Oncogene 15, 2553. Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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