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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

553210 Sigma-AldrichRapamycin - CAS 53123-88-9 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 553210) on sigmaaldrich.com.

Rapamycin - CAS 53123-88-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
数据表
Data Sheet
Citations
Posters

同义词: mTOR Inhibitor I

Primary Target: Mammalian target of rapamycin (mTOR)

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
53123-88-9	C₅₁H₇₉NO₁₃

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
553210-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC₅₀ = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser⁴⁷³ appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110^Rb phosphorylation, p34^cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
Catalogue Number	553210
Brand Family	Calbiochem®
Synonyms	mTOR Inhibitor I

References
References	Chen, T., et al. 2011. Aging Cell. 10, 908. Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794. Braun, W., et al. 1995. FASEB J. 9, 63. Nielsen, F.C., et al. 1995. Nature 377, 358. Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493. Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350. Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734. Terada, N., et al. 1993. J. Biol. Chem. 268, 12062. Kuo, J., et al. 1992. Nature 358, 70. Price, D.J., et al. 1992. Science 257, 973. Heitman, J., et al. 1991. Science 253, 905. Kay, J.E., et al. 1991. Immunology 72, 544. Schreiber, S.L. 1991. Science 251, 283. Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231. Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

References

Chen, T., et al. 2011. Aging Cell. 10, 908.
Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
Braun, W., et al. 1995. FASEB J. 9, 63.
Nielsen, F.C., et al. 1995. Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
Kuo, J., et al. 1992. Nature 358, 70.
Price, D.J., et al. 1992. Science 257, 973.
Heitman, J., et al. 1991. Science 253, 905.
Kay, J.E., et al. 1991. Immunology 72, 544.
Schreiber, S.L. 1991. Science 251, 283.
Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

Product Information
CAS number	53123-88-9
ATP Competitive	N
Form	Clear film
Hill Formula	C₅₁H₇₉NO₁₃
Chemical formula	C₅₁H₇₉NO₁₃
Reversible	N
Structure formula Image
Quality Level	MQ200

Applications

Biological Information
Primary Target	Mammalian target of rapamycin (mTOR)
Primary Target IC<sub>50</sub>	50 pM against p70 S6 kinase
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	VE6250000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
553210-1MGCN	04055977193480
553210-5MGCN	04055977193534

Documentation

Rapamycin - CAS 53123-88-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Rapamycin - CAS 53123-88-9 - Calbiochem 分析证书

标题	批号
553210	输入批号

参考

参考信息概述
Chen, T., et al. 2011. Aging Cell. 10, 908. Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794. Braun, W., et al. 1995. FASEB J. 9, 63. Nielsen, F.C., et al. 1995. Nature 377, 358. Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493. Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350. Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734. Terada, N., et al. 1993. J. Biol. Chem. 268, 12062. Kuo, J., et al. 1992. Nature 358, 70. Price, D.J., et al. 1992. Science 257, 973. Heitman, J., et al. 1991. Science 253, 905. Kay, J.E., et al. 1991. Immunology 72, 544. Schreiber, S.L. 1991. Science 251, 283. Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231. Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

参考信息概述

小册子

标题
Bulk Product Guide
Caspases and other Apoptosis Related Tools Brochure

数据表

标题
Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

海报

标题
Human Kinome & InhibitorSelect™ Libraries

引用

标题

Chen, T., et al. 2011. Aging Cell. 10, 908.

Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533.

Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374.

Liao, X., et al. 2003. Endocrinology 144, 1656.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-September-2014 JSW
Synonyms	mTOR Inhibitor I
Description	Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC₅₀ = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser⁴⁷³ appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110^Rb phosphorylation, p34^cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase.
Form	Clear film
CAS number	53123-88-9
RTECS	VE6250000
Chemical formula	C₅₁H₇₉NO₁₃
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (200 mg/ml) or Ethanol (50 mg/ml)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 8114
References	Chen, T., et al. 2011. Aging Cell. 10, 908. Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794. Braun, W., et al. 1995. FASEB J. 9, 63. Nielsen, F.C., et al. 1995. Nature 377, 358. Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493. Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350. Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734. Terada, N., et al. 1993. J. Biol. Chem. 268, 12062. Kuo, J., et al. 1992. Nature 358, 70. Price, D.J., et al. 1992. Science 257, 973. Heitman, J., et al. 1991. Science 253, 905. Kay, J.E., et al. 1991. Immunology 72, 544. Schreiber, S.L. 1991. Science 251, 283. Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231. Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
Citation	Chen, T., et al. 2011. Aging Cell. 10, 908. Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533. Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374. Liao, X., et al. 2003. Endocrinology 144, 1656.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Akt (Protein Kinase B) Inhibitors

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