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			96-Well Plate

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553502 Sigma-AldrichRac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC₅₀ ~50 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: NSC23766

Primary Target: Rac1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1177865-17-6	C₂₄H₃₈Cl₃N₇

价格及供货情况

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Description
Overview	A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC₅₀ ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC₅₀ = 50 mM and 64 mM, respectively).
Catalogue Number	553502
Brand Family	Calbiochem®
Synonyms	NSC23766

References
References	Dwivedi, S., et al. 2010. J. Translational Med. 8, 128. Desire, L., et al. 2005. J. Biol. Chem. 280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.

Product Information
CAS number	1177865-17-6
ATP Competitive	N
Form	Lyophilized
Hill Formula	C₂₄H₃₈Cl₃N₇
Chemical formula	C₂₄H₃₈Cl₃N₇
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Rac1
Primary Target IC<sub>50</sub>	~50 µM against Rac1 GDP/GTP exchange activity; 50 mM and 64 mM against TRAP-induced and collagen stimulated platelet aggregation
Purity	≥93% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
553502-10MGCN	04055977193626
553502-5MGCN	07790788051433

Documentation

Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem 分析证书

标题	批号
553502	输入批号

参考

参考信息概述
Dwivedi, S., et al. 2010. J. Translational Med. 8, 128. Desire, L., et al. 2005. J. Biol. Chem. 280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.

引用

标题

Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-February-2012 RFH
Synonyms	NSC23766
Description	A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC₅₀ ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC₅₀ = 50 mM and 64 mM, respectively).
Form	Lyophilized
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1177865-17-6
Chemical formula	C₂₄H₃₈Cl₃N₇
Structure formula
Purity	≥93% by HPLC
Solubility	H₂O (5 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Dwivedi, S., et al. 2010. J. Translational Med. 8, 128. Desire, L., et al. 2005. J. Biol. Chem. 280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
Citation	Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Rac Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > GTPase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > G-Protein Coupled Receptor Agonists

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