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			96-Well Plate

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559286 Sigma-AldrichRSK Inhibitor II - CAS 501437-28-1 - Calbiochem

The RSK Inhibitor II, also referenced under CAS 501437-28-1, controls the biological activity of RSK. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: 2-(3,5-Difluoro-4-hydroxy-anilino)-8-isopentyl-5,7-dimethyl-7H-pteridin-6-one, racemic, p90 Ribosomal S6 Kinase Inhibitor II, BI-D1870, BID-1870, BID1870

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
501437-28-1	C₁₉H₂₃F₂N₅O₂

价格及供货情况

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Description
Overview	The racemic mixture of a cell-permeable dihydropteridinone that acts as a potent and selective RSK inhibitor (IC₅₀ ≤31 nM against RSK1, 2, 3, and 4; [ATP] = 100 µM) by targeting RSK N-terminal kinase domain in an ATP-competitive manner, while inhibiting 11 other kinases only at higher concentrations (IC₅₀ ≥100 nM) and displaying little activity against 39 others. Shown to selectively inhibit RSK-dependent, but not RSK-independent, cellular protein phosphorylations in PMA-stimulated HEK-293 cells and EGF-stimulated Rat-2 cells (IC₅₀ ~1 µM).
Catalogue Number	559286
Brand Family	Calbiochem®
Synonyms	2-(3,5-Difluoro-4-hydroxy-anilino)-8-isopentyl-5,7-dimethyl-7H-pteridin-6-one, racemic, p90 Ribosomal S6 Kinase Inhibitor II, BI-D1870, BID-1870, BID1870

References
References	Carriere, A., et al. 2008. Curr. Biol. 18, 1269 Sapkota, G.P., et al. 2007. Biochem. J. 401, 29. Zaru, R., et al. 2007. Nat. Immunol. 8, 1227.

Product Information
CAS number	501437-28-1
Form	Off-white solid
Hill Formula	C₁₉H₂₃F₂N₅O₂
Chemical formula	C₁₉H₂₃F₂N₅O₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
559286-5MGCN	04055977192377

Documentation

RSK Inhibitor II - CAS 501437-28-1 - Calbiochem 分析证书

标题	批号
559286	输入批号

参考

参考信息概述
Carriere, A., et al. 2008. Curr. Biol. 18, 1269 Sapkota, G.P., et al. 2007. Biochem. J. 401, 29. Zaru, R., et al. 2007. Nat. Immunol. 8, 1227.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-April-2012 JSW
Synonyms	2-(3,5-Difluoro-4-hydroxy-anilino)-8-isopentyl-5,7-dimethyl-7H-pteridin-6-one, racemic, p90 Ribosomal S6 Kinase Inhibitor II, BI-D1870, BID-1870, BID1870
Description	The racemic mixture of a cell-permeable dihydropteridinone that acts as a potent and selective RSK inhibitor (IC₅₀ = 31, 24, 18, and 15 nM against RSK1, 2, 3, and 4, respectively; [ATP] = 100 µM) by targeting RSK N-terminal kinase domain in an ATP-competitive manner, while inhibiting 11 other kinases only at higher concentrations (IC₅₀ ≥100 nM) and displaying little activity against 39 others. Shown to selectively inhibit RSK-dependent, but not RSK-independent, cellular protein phosphorylations in PMA-stimulated human HEK-293 cells and EGF-stimulated rat Rat-2 cells (IC₅₀ ~1 µM). A useful pharmacological reagent for studying RSK-mediated cellular signaling events.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	501437-28-1
Chemical formula	C₁₉H₂₃F₂N₅O₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Carriere, A., et al. 2008. Curr. Biol. 18, 1269 Sapkota, G.P., et al. 2007. Biochem. J. 401, 29. Zaru, R., et al. 2007. Nat. Immunol. 8, 1227.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > S6K Inhibitors

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