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557352 Sigma-AldrichRORα/γ Agonist, SR1078 - CAS 1246525-60-9 - Calbiochem

The RORα/γ Agonist, SR1078 controls the biological activity of RORα/γ. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: SR1078, N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide

Primary Target: RORα/γ

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1246525-60-9	C₁₇H₁₀F₉NO₂

价格及供货情况

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Description
Overview	A cell-permeable diaryl amide derived from T1317 (a known LXR agonist and retinoic acid receptor (ROR) inverse agonist) that acts as a highly selective agonist of RORα/γ and does not exhibit affinity for FXR, LXRa and LXRb. Shown to stabilize p53 in cancer cells and increase the expression of p21 and PUMA. Induces apoptosis in hepatocellular carcinoma (HepG2) cells in a RORα and p53-dependent process. Also reported to increase the expression of Sox4 and REV-ERBα in HepG2 cells. Exhibits suitable pharmacokinetic properties with sustained plasma levels even after 8 hours following a single i.p. injection. Exposure to SR1078 Induces expression of glucose-6-phosphatase and fibroblast growth factor 21 in murine models (10 mg/kg/i.p).
Catalogue Number	557352
Brand Family	Calbiochem®
Synonyms	SR1078, N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide

References
References	Wang, Y., et al. 2010. ACS Chem Biol. 5, 1029.PLoS One.7, e34921.

Product Information
CAS number	1246525-60-9
Form	White solid
Hill Formula	C₁₇H₁₀F₉NO₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	RORα/γ
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
557352-10MGCN	04055977267952

Documentation

RORα/γ Agonist, SR1078 - CAS 1246525-60-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

RORα/γ Agonist, SR1078 - CAS 1246525-60-9 - Calbiochem 分析证书

标题	批号
557352	输入批号

参考

参考信息概述
Wang, Y., et al. 2010. ACS Chem Biol. 5, 1029.PLoS One.7, e34921.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-August-2012 JSW
Synonyms	SR1078, N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide
Description	A cell-permeable diaryl amide derived from T1317 (a known LXR agonist and retinoic acid receptor (ROR) inverse agonist) that acts as a highly selective agonist of RORα/γ and does not exhibit affinity for FXR, LXRa and LXRb. Shown to stabilize p53 in cancer cells and increase the expression of p21 and PUMA. Induces apoptosis in hepatocellular carcinoma (HepG2) cells in a RORα and p53-dependent process. Also reported to increase the expression of Sox4 and REV-ERBα in HepG2 cells. Exhibits suitable pharmacokinetic properties with sustained plasma levels even after 8 hours following a single i.p. injection. Exposure to SR1078 Induces expression of glucose-6-phosphatase and fibroblast growth factor 21 in murine models (10 mg/kg/i.p).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1246525-60-9
Structure formula
Purity	≥99% by HPLC
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Wang, Y., et al. 2010. ACS Chem Biol. 5, 1029.PLoS One.7, e34921.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Other Activators/Agonists

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