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554716 Sigma-AldrichREV-ERBα Agonist, GSK4112 - CAS 1216744-19-2 - Calbiochem

The REV-ERBα Agonist, GSK4112 controls the biological activity of REV-ERBα. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: GSK4112

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1216744-19-2	C₁₈H₂₁ClN₂O₄S

价格及供货情况

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Description
Overview	A selective, cell-permeable ligand (EC₅₀ = 250 nM) that acts as a REV-ERBα agonist using a FRET assay. It enhances the recruitment of NCoR peptide to REV-ERBα by up to 70%, and displays no activity towards LRH1, SF1, FXR or ROR, and LXR. Furthermore, it inhibits the promoter activity of Pai1, a known target for REV-ERBα by 30%. This ligand exhibits acute suppression of Bmal1 transcription, and is capable of resetting the molecular rhythm of REV-ERBα-mediated PER2 expression in both Rat-1 lung fibroblasts and on ectopic lung tissues in Luciferase reporter assays. In addition, it is shown to repress the expression of gluconeogenic genes in liver cells and reduce glucose output in primary hepatocytes.
Catalogue Number	554716
Brand Family	Calbiochem®
Synonyms	GSK4112

References
References	Grant, D., et al. 2010, ACS Chem. Biol. 5, 925. Meng, Q., et al. 2008. Journ. Cell. Sci 121, 3629.

Product Information
CAS number	1216744-19-2
Form	Dark beige solid
Hill Formula	C₁₈H₂₁ClN₂O₄S
Chemical formula	C₁₈H₂₁ClN₂O₄S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
554716-10MGCN	04055977193091

Documentation

REV-ERBα Agonist, GSK4112 - CAS 1216744-19-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

REV-ERBα Agonist, GSK4112 - CAS 1216744-19-2 - Calbiochem 分析证书

标题	批号
554716	输入批号

参考

参考信息概述
Grant, D., et al. 2010, ACS Chem. Biol. 5, 925. Meng, Q., et al. 2008. Journ. Cell. Sci 121, 3629.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-November-2011 RFH
Synonyms	GSK4112
Description	A selective, cell-permeable ligand (EC₅₀ = 250 nM) that acts as a REV-ERBα agonist using a FRET assay. It enhances the recruitment of NCoR peptide to REV-ERBα by up to 70%, and displays no activity towards LRH1, SF1, FXR or ROR, and LXR. Furthermore, it inhibits the promoter activity of Pai1, a known target for REV-ERBα by 30%. This ligand exhibits acute suppression of Bmal1 transcription, and is capable of resetting the molecular rhythm of REV-ERBα-mediated PER2 expression in both Rat-1 lung fibroblasts and on ectopic lung tissues in Luciferase reporter assays. In addition, it is shown to repress the expression of gluconeogenic genes in liver cells and reduce glucose output in primary hepatocytes.
Form	Dark beige solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1216744-19-2
Chemical formula	C₁₈H₂₁ClN₂O₄S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Grant, D., et al. 2010, ACS Chem. Biol. 5, 925. Meng, Q., et al. 2008. Journ. Cell. Sci 121, 3629.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Other Activators/Agonists

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