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551600 Sigma-AldrichQuercetin, Dihydrate - CAS 6151-25-3 - Calbiochem

A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 3,3ʹ,4ʹ,5,7-Pentahydroxyflavone

Primary Target: PI 3-kinase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
6151-25-3	C₁₅H₁₀O₇ · 2H₂O

价格及供货情况

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Description
Overview	A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A₂ (IC₅₀ = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
Catalogue Number	551600
Brand Family	Calbiochem®
Synonyms	3,3ʹ,4ʹ,5,7-Pentahydroxyflavone

References
References	Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604. Howitz, K.T., et al. 2003. Nature 425, 191. Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952. Shibasaki, F., et al. 1993. Biochem. J. 289, 227. Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624. Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227. Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583. Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444. Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535. Beretz, A., et al. 1978. Experientia 34, 1054.

References

Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
Howitz, K.T., et al. 2003. Nature 425, 191.
Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
Beretz, A., et al. 1978. Experientia 34, 1054.

Product Information
CAS number	6151-25-3
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₁₅H₁₀O₇ · 2H₂O
Chemical formula	C₁₅H₁₀O₇ · 2H₂O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PI 3-kinase
Primary Target IC<sub>50</sub>	43 nM, 3.8 µM, 2 µM against PIM1 kinase, PI 3-K, and phospholipase A2, respectively
Purity	>95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	LK8950000

Safety Information
R Phrase	R: 25-40 Toxic if swallowed. Limited evidence of a carcinogenic effect.
S Phrase	S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+15°C to +30°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
551600-100MGCN	07790788051426

Documentation

Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem 分析证书

标题	批号
551600	输入批号

参考

参考信息概述
Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604. Howitz, K.T., et al. 2003. Nature 425, 191. Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952. Shibasaki, F., et al. 1993. Biochem. J. 289, 227. Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624. Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227. Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583. Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444. Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535. Beretz, A., et al. 1978. Experientia 34, 1054.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-June-2009 JSW
Synonyms	3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
Description	A cell-permeable inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A₂ (IC₅₀ = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
Form	Yellow solid
CAS number	6151-25-3
RTECS	LK8950000
Chemical formula	C₁₅H₁₀O₇ · 2H₂O
Structure formula
Purity	>95% by HPLC
Solubility	Acetic Acid (1 mg/ml), Aqueous Alkali (1 mg/ml), or DMSO (5 mg/ml)
Storage	Protect from light +15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Toxicity	Toxic & Carcinogenic / Teratogenic
Merck USA index	14, 8034
References	Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604. Howitz, K.T., et al. 2003. Nature 425, 191. Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952. Shibasaki, F., et al. 1993. Biochem. J. 289, 227. Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624. Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227. Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583. Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444. Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535. Beretz, A., et al. 1978. Experientia 34, 1054.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Phospholipase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Phosphatidylinositol 3-Kinase (PI 3-kinase) Inhibitors

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