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540500 Sigma-AldrichPurvalanol A - CAS 212844-53-6 - Calbiochem

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

Purvalanol A - CAS 212844-53-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine

Primary Target: Cdc2/cyclin B

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
212844-53-6	C₁₉H₂₅ClN₆O

价格及供货情况

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Description
Overview	A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2/cyclin B; IC₅₀ = 70 nM for Cdk2/cyclin A; IC₅₀ = 35 nM for Cdk2/cyclin E; and IC₅₀ = 75 nM for Cdk5/p35).
Catalogue Number	540500
Brand Family	Calbiochem®
Synonyms	2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine

References
References	Gray, N.S., et al. 1998. Science 281, 533.

Product Information
CAS number	212844-53-6
ATP Competitive	N
Declaration	Sold under license of U.S. Patents 6,617,331 and 6,803,371.
Form	Off-white solid
Hill Formula	C₁₉H₂₅ClN₆O
Chemical formula	C₁₉H₂₅ClN₆O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Cdc2/cyclin B
Primary Target IC<sub>50</sub>	4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
540500-1MGCN	04055977268812

Documentation

Purvalanol A - CAS 212844-53-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Purvalanol A - CAS 212844-53-6 - Calbiochem 分析证书

标题	批号
540500	输入批号

参考

参考信息概述
Gray, N.S., et al. 1998. Science 281, 533.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-December-2009 RFH
Synonyms	2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
Description	A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2-cyclin B; IC₅₀ = 70 nM for Cdk2-cyclin A; IC₅₀ = 35 nM for Cdk2-cyclin E; and IC₅₀ = 75 nM for Cdk5-p35).
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	212844-53-6
Chemical formula	C₁₉H₂₅ClN₆O
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Standard Handling
References	Gray, N.S., et al. 1998. Science 281, 533.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors

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