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540220 Sigma-AldrichPurmorphamine - CAS 483367-10-8 - Calbiochem

A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM).

Purmorphamine - CAS 483367-10-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist

Primary Target: Activation of the Hedgehog signaling pathway

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
483367-10-8	C₃₁H₃₂N₆O₂

价格及供货情况

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Description
Overview	A cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	540220
Brand Family	Calbiochem®
Synonyms	2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist

References
References	Wu, X., et al. 2004. Chem. Biol. 11, 1229. Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.

Product Information
CAS number	483367-10-8
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₃₁H₃₂N₆O₂
Chemical formula	C₃₁H₃₂N₆O₂
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	Activation of the Hedgehog signaling pathway
Primary Target IC<sub>50</sub>	EC50 = 1 µM for inducing osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 22-68 Harmful if swallowed. Possible risks of irreversible effects.
S Phrase	S: 22-36/37 Do not breathe dust. Wear suitable protective clothing and gloves.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
540220-20MGCN	04055977268737
540220-5MGCN	07790788051389

Documentation

Purmorphamine - CAS 483367-10-8 - Calbiochem 分析证书

标题	批号
540220	输入批号

参考

参考信息概述
Wu, X., et al. 2004. Chem. Biol. 11, 1229. Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-November-2014 JSW
Synonyms	2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
Description	A cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC₅₀ = 1 µM) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	483367-10-8
Chemical formula	C₃₁H₃₂N₆O₂
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (200 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful
References	Wu, X., et al. 2004. Chem. Biol. 11, 1229. Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Inducers > Cell Differentiation Inducers

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