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523310 Sigma-AldrichPterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem

A cell-permeable methoxylated analog of Resveratrol that displays antioxidant, antiproliferative, and hypoglycemic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: trans-3,5-Dimethoxy-4ʹ-hydroxystilbene

Primary Target: COX-1 and COX-2 activities

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
537-42-8	C₁₆H₁₆O₃

价格及供货情况

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Description
Overview	A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, antiproliferative, and hypoglycemic properties. Moderately inhibits COX-1 and -2 activities (IC₅₀ = 19.8 µM and 83.9 µM) respectively, induces apoptosis in HL60 cells (IC₅₀ = 70 µM), prevents DMBA-induced preneoplastic lesions (ED₅₀ = 4.8 µM) and decreases plasma glucose level in streptozotocin-induced diabetic rats comparable to that of Metformin.
Catalogue Number	523310
Brand Family	Calbiochem®
Synonyms	trans-3,5-Dimethoxy-4ʹ-hydroxystilbene

References
References	Roberti, M., et al. 2003. J. Med. Chem. 46, 3546. Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453. Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.

Product Information
CAS number	537-42-8
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₁₆H₁₆O₃
Chemical formula	C₁₆H₁₆O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	COX-1 and COX-2 activities
Primary Target IC<sub>50</sub>	19.8 µM, 83.9 µM against COX-1 and -2 activities, respectively; 70 µM for inducing apoptosis in HL60 cells; ED50 = 4.8 µM for preventing DMBA-induced preneoplastic lesions
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
523310-10MGCN	04055977271485

Documentation

Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem 分析证书

标题	批号
523310	输入批号

参考

参考信息概述
Roberti, M., et al. 2003. J. Med. Chem. 46, 3546. Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453. Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-October-2007 JSW
Synonyms	trans-3,5-Dimethoxy-4ʹ-hydroxystilbene
Description	A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox^® (Cat. No. 64847). Moderately inhibits COX-1 & COX-2 activities (IC₅₀ = 19.8 µM & 83.9 µM, respectively) and induces apoptosis in HL60 cells (IC₅₀ = 70 µM). Also prevents DMBA-induced pre-neoplastic lesions (ED₅₀ = 4.8 µM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	537-42-8
Chemical formula	C₁₆H₁₆O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml) or Methanol (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Roberti, M., et al. 2003. J. Med. Chem. 46, 3546. Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453. Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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