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539690 Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem

The Protein Synthesis Initiation Inhibitor, NSC 119889 blocks 5'-mediated/cap-dependent initiation of protein synthesis. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 3,4,5,6-Tetrabromofluorescein

Primary Target: human arginine methyl transferase
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539690
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概述

Replacement Information

重要规格表

Empirical Formula
C₂₀H₈Br₄O₅

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
539690-25MGCN
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      		 塑胶安瓿;塑胶针药瓶 25 mg
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      Description
      OverviewA cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
      Catalogue Number539690
      Brand Family Calbiochem®
      Synonyms3,4,5,6-Tetrabromofluorescein
      References
      ReferencesNovac, O., et al. 2004. Nucleic Acids Res. 32, 902.
      Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.
      Product Information
      ATP CompetitiveN
      FormLight brown solid
      Hill FormulaC₂₀H₈Br₄O₅
      Chemical formulaC₂₀H₈Br₄O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targethuman arginine methyl transferase
      Primary Target IC<sub>50</sub>1.41 µM against human arginine methyl transferase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      539690-25MGCN 04055977194227

      Documentation

      Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem 分析证书

      标题批号
      539690

      参考

      参考信息概述
      Novac, O., et al. 2004. Nucleic Acids Res. 32, 902.
      Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-September-2007 JSW
      Synonyms3,4,5,6-Tetrabromofluorescein
      DescriptionA cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5'-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
      FormLight brown solid
      Chemical formulaC₂₀H₈Br₄O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or Methanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesNovac, O., et al. 2004. Nucleic Acids Res. 32, 902.
      Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.