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539211 Sigma-AldrichProtein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem

The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
17372-87-1	C₂₉H₆Br₄O₅Na₂ • 3H₂O

价格及供货情况

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Description
Overview	A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC₅₀ against yeast Hmt1p & human PRMT1 = 0.78 and 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 and Suv39H2).
Catalogue Number	539211
Brand Family	Calbiochem®
Synonyms	Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III

References
References	Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.

Product Information
CAS number	17372-87-1
Form	Reddish brown solid
Hill Formula	C₂₉H₆Br₄O₅Na₂ • 3H₂O
Chemical formula	C₂₉H₆Br₄O₅Na₂ • 3H₂O
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥90%

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 24/25-36/37/39-45 Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
539211-50MGCN	04055977268911

Documentation

Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Protein Methyltransferase Inhibitor, AMI-5 - CAS 17372-87-1 - Calbiochem 分析证书

标题	批号
539211	输入批号

参考

参考信息概述
Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-May-2009 RFH
Synonyms	Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
Description	A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC₅₀ against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).
Form	Reddish brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	17372-87-1
Chemical formula	C₂₉H₆Br₄O₅Na₂ • 3H₂O
Structure formula
Purity	≥90%
Solubility	H₂O (50 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Cheng, D., et al. 2004. J. Biol. Chem. 279, 23892.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors

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