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Recombinant, human prion protein (amino acids 23-231) fused to a His•Tag® sequence and expressed in E. coli. Useful as an antigen standard in immunochemical detection of Creutzfeldt-Jakob Disease (CJD).
Catalogue Number
530006
Brand Family
Calbiochem®
Synonyms
rhPrPc
References
References
Calzolai, L., and Zahn, R. 2003. J. Biol. Chem.278, 35592. Prusiner, S.B. 1998. Proc. Natl. Acad. Sci. USA95, 13363. Swietnicki, W., et al. 1997. J. Biol. Chem.272, 27517. Pan, K.M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 10962. Basler, K., et al. 1986. Cell46, 417.
Prion Protein, His•Tag®, Human, Recombinant, E. coli 分析证书
标题
批号
530006
参考
参考信息概述
Calzolai, L., and Zahn, R. 2003. J. Biol. Chem.278, 35592. Prusiner, S.B. 1998. Proc. Natl. Acad. Sci. USA95, 13363. Swietnicki, W., et al. 1997. J. Biol. Chem.272, 27517. Pan, K.M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 10962. Basler, K., et al. 1986. Cell46, 417.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
29-August-2008 RFH
Synonyms
rhPrPc
Description
Recombinant, human prion protein (amino acids 23-231) fused to a His•Tag® sequence and expressed in E. coli. Prion diseases or transmissible spongiform encephalopathies are neurodegenerative diseases that affect both humans and animals. All prion diseases share the same molecular pathogenic mechanism that involves conversion of normal cellular prion protein (PrPc) into a form that is insoluble in non-ionic detergent and partially resistant to proteases (PrPsc). Useful as an antigen standard in immunochemical detection of Creutzfeldt-Jakob Disease (CJD).
Form
Liquid
Formulation
In 10 mM sodium acetate, pH 4.0.
Purity
≥95% by SDS-PAGE
Storage
Avoid freeze/thaw
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C).
Toxicity
Standard Handling
References
Calzolai, L., and Zahn, R. 2003. J. Biol. Chem.278, 35592. Prusiner, S.B. 1998. Proc. Natl. Acad. Sci. USA95, 13363. Swietnicki, W., et al. 1997. J. Biol. Chem.272, 27517. Pan, K.M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 10962. Basler, K., et al. 1986. Cell46, 417.