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416154 Sigma-AldrichPre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem

Pre-mRNA Splicing Inhibitor, Isoginkgetin, CAS 548-19-6, is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
548-19-6	C₃₂H₂₂O₁₀

价格及供货情况

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Description
Overview	A cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (IC_max = 50 µM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
Catalogue Number	416154
Brand Family	Calbiochem®
Synonyms	8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

References
References	Kim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265. O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147. Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.

Product Information
CAS number	548-19-6
Form	Yellow solid
Hill Formula	C₃₂H₂₂O₁₀
Chemical formula	C₃₂H₂₂O₁₀
Structure formula Image
Quality Level	MQ100

Applications
Application	Pre-mRNA Splicing Inhibitor, Isoginkgetin, CAS 548-19-6, is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
416154-10MGCN	04055977187786

Documentation

Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem 分析证书

标题	批号
416154	输入批号

参考

参考信息概述
Kim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265. O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147. Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	26-September-2012 JSW
Synonyms	8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
Description	A naturally isolated Ginkgo biloba biflavanoid that acts as a cell-permeable, reversible inhibitor against spliceosome-mediated pre-mRNA splicing (IC₅₀ and IC_max = 30 and 50 µM, respectively, in splicing assays using HeLa nuclear extract) by preventing the prespliceosome A complex from recruiting the U4/U5/U6 tri-snRNP (stable nuclear RNA and its associated proteins) to form B complex. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	548-19-6
Chemical formula	C₃₂H₂₂O₁₀
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Kim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265. O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147. Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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