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524403 Sigma-AldrichPravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (K_i = ~1 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na

Primary Target: AMG-CoA reductase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
81131-70-6	C₂₃H₃₅O₇.Na

价格及供货情况

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Description
Overview	A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (K_i = ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
Catalogue Number	524403
Brand Family	Calbiochem®
Synonyms	(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na

References
References	Kwak, B., et al. 2000. Natl. Med. 6, 1399. Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26. Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798. Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203. Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115. Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179

Product Information
CAS number	81131-70-6
ATP Competitive	N
Form	White crystalline solid
Hill Formula	C₂₃H₃₅O₇.Na
Chemical formula	C₂₃H₃₅O₇.Na
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	AMG-CoA reductase
Primary Target K<sub>i</sub>	~1 nM inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocking in vivo cholesterol synthesis
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	QJ7185000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Environmental Hazard
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
524403-25MGCN	04055977270983

Documentation

Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem 分析证书

标题	批号
524403	输入批号

参考

参考信息概述
Kwak, B., et al. 2000. Natl. Med. 6, 1399. Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26. Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798. Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203. Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115. Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-May-2008 RFH
Synonyms	(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na
Description	A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks in vivo cholesterol synthesis (K_i ~1 nM). Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
Form	White crystalline solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	81131-70-6
RTECS	QJ7185000
Chemical formula	C₂₃H₃₅O₇.Na
Structure formula
Purity	≥98% by HPLC
Solubility	H₂O (100 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Environmental Hazard
Merck USA index	14, 7714
References	Kwak, B., et al. 2000. Natl. Med. 6, 1399. Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26. Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798. Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203. Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115. Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > HMG-CoA (3-Hydroxy-3-Methylglutaryl Coenzyme A) Reductase Inhibitors

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524403 Sigma-AldrichPravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (K_i = ~1 nM).

同义词: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na

Recommended Products

概述

重要规格表

价格及供货情况

Documentation

Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem MSDS

Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem 分析证书

参考

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A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM).

同义词: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na

Recommended Products

重要规格表

价格及供货情况

Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem MSDS

Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem 分析证书

参考

种类

最近查看的内容

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (K_i = ~1 nM).