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Native, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds to fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
Catalogue Number
528240
Brand Family
Calbiochem®
Synonyms
GPIIbIIIa, Fibrinogen Receptor, CD41/CD61
References
References
Schwarz M., et al. 2004. J. Pharmacol. Exp. Therap.308, 1002. Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
Product Information
Form
Liquid
Formulation
In 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl₂, 50% glycerol, ≤0.1% sodium azide, pH 7.4.
Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets 分析证书
标题
批号
528240
参考
参考信息概述
Schwarz M., et al. 2004. J. Pharmacol. Exp. Therap.308, 1002. Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
28-January-2021 JSW
Synonyms
GPIIbIIIa, Fibrinogen Receptor, CD41/CD61
Description
Native, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
Form
Liquid
Formulation
In 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl₂, 50% glycerol, ≤0.1% sodium azide, pH 7.4.
Concentration Label
Please refer to vial label for lot-specific concentration
Source
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Storage
≤ -70°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.
Toxicity
Standard Handling
References
Schwarz M., et al. 2004. J. Pharmacol. Exp. Therap.308, 1002. Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
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