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Native plasminogen from human plasma. Plasminogen is a single chain glycoprotein found in normal plasma at ~12 mg per deciliter, and is the inactive precursor of the serine protease plasmin.
Catalogue Number
528175
Brand Family
Calbiochem®
Synonyms
Profibrinolysin, Plasma Trypsinogen
References
References
Sun, Z., et al. 2002. Biochim. Biophys. Acta1596, 182. Robbins, K.C., et al. 1967. J. Biol. Chem.242, 2333.
Product Information
CAS number
9001-91-6
Unit of Definition
One unit is defined as the amount of enzyme that will hydrolyze 1 µmol of N-tosyl-Arg ethyl ester in 30 min at 37°C, pH 8.0.
Form
Lyophilized
Formulation
Lyophilized from 20 mM Tris-HCl, 2 mM EDTA, pH 7.5.
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity
≥120 units/mg protein.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R Phrase
R: 36/37/38
Irritating to eyes, respiratory system and skin.
S Phrase
S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Irritant
Storage
-20°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 2 months at -20°C.
Sun, Z., et al. 2002. Biochim. Biophys. Acta1596, 182. Robbins, K.C., et al. 1967. J. Biol. Chem.242, 2333.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
16-May-2008 RFH
Synonyms
Profibrinolysin, Plasma Trypsinogen
Description
Native plasminogen from human plasma. Single chain glycoprotein containing 790 amino acid residues. Found in normal plasma at about 12 mg/100 ml. Inactive precursor of the serine protease plasmin. Plasminogen is converted to the active protease by cleavage at Arg560.
Form
Lyophilized
Formulation
Lyophilized from 20 mM Tris-HCl, 2 mM EDTA, pH 7.5.
Source
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number
9001-91-6
Purity
≥95% by SDS-PAGE
Specific activity
≥120 units/mg protein.
Unit definition
One unit is defined as the amount of enzyme that will hydrolyze 1 µmol of N-tosyl-Arg ethyl ester in 30 min at 37°C, pH 8.0.
Solubility
H₂O
Storage
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 2 months at -20°C.
Toxicity
Irritant
Merck USA index
14, 7521
References
Sun, Z., et al. 2002. Biochim. Biophys. Acta1596, 182. Robbins, K.C., et al. 1967. J. Biol. Chem.242, 2333.
