Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.
Following reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against β-amyloid and glutamate-induced apoptosis.
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
63208-82-2
Chemical formula
C₁₆H₁₈N₂OS·HBr
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (100 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
Toxicity
Standard Handling
References
Murphy, P.J.M., et al. 2004. J. Biol. Chem.279, 30195. Culmsee, C., et al. 2001. J. Neurochem.77, 220. Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41. Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98. Ferber, D. 1999. Science 285, 1651. Jacquemin-Sablon, A. 1999. Bull. Cancer86, 894. Komarov, P.G., et al. 1999. Science 285, 1733.
