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524400 Sigma-AldrichPhorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: PMA, TPA, PKC Activator I

Primary Target: Protein Kinase C

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
16561-29-8	C₃₆H₅₆O₈

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
524400-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca²⁺-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mM solution in DMSO (Cat. No. 500582).
Catalogue Number	524400
Brand Family	Calbiochem®
Synonyms	PMA, TPA, PKC Activator I

References
References	Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443. Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168. Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846. Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101. Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937. Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011. Saltis, J., et al. 1991. J. Biol. Chem. 266, 261. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774. Perchellet, J. 1985. Carcinogenesis 6, 567. Nishizuka, Y. 1984. Science 255, 1365. Mastro, A. 1982. Lymphokines 6, 263.

References

Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
Perchellet, J. 1985. Carcinogenesis 6, 567.
Nishizuka, Y. 1984. Science 255, 1365.
Mastro, A. 1982. Lymphokines 6, 263.

Product Information
CAS number	16561-29-8
ATP Competitive	N
Form	White solid
Hill Formula	C₃₆H₅₆O₈
Chemical formula	C₃₆H₅₆O₈
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.

Biological Information
Primary Target	Protein Kinase C
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	QH4377000

Safety Information
R Phrase	R: 21-38 Harmful in contact with skin. Irritating to skin.
S Phrase	S: 26-27-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Take off immediately all contaminated clothing. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
524400-10MGCN	04055977270952
524400-1MGCN	04055977270945
524400-25MGCN	04055977270969
524400-5MGCN	04055977270976

Documentation

Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem 分析证书

标题	批号
524400	输入批号

参考

参考信息概述
Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443. Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168. Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846. Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101. Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937. Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011. Saltis, J., et al. 1991. J. Biol. Chem. 266, 261. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774. Perchellet, J. 1985. Carcinogenesis 6, 567. Nishizuka, Y. 1984. Science 255, 1365. Mastro, A. 1982. Lymphokines 6, 263.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.

Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.

Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.

Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-October-2010 JSW
Synonyms	PMA, TPA, PKC Activator I
Description	Extremely potent mouse skin tumor promoter. Activates protein kinase C (PKC) in vivo and in vitro, even at nanomolar concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca²⁺-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Most commonly used phorbol ester.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	16561-29-8
RTECS	QH4377000
Chemical formula	C₃₆H₅₆O₈
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (10 mg/ml). Further dilute with aqueous buffers just prior to use.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
Toxicity	Harmful
References	Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443. Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168. Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846. Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101. Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937. Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011. Saltis, J., et al. 1991. J. Biol. Chem. 266, 261. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774. Perchellet, J. 1985. Carcinogenesis 6, 567. Nishizuka, Y. 1984. Science 255, 1365. Mastro, A. 1982. Lymphokines 6, 263.
Citation	Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055. Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346. Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515. Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Kinases Activators > Protein Kinase C Activators

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