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			96-Well Plate

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524488 Sigma-AldrichPhloretin - CAS 60-82-2 - Calbiochem

A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM).

Phloretin - CAS 60-82-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone

Primary Target: PKC

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
60-82-2	C₁₅H₁₄O₅

价格及供货情况

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Description
Overview	A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM). Activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca²⁺ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F_2α receptors linked to phospholipase C in astrocytes.
Catalogue Number	524488
Brand Family	Calbiochem®
Synonyms	2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone

References
References	Berry, G.T., et al. 1994. Pediat. Res. 35, 141. Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167. Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410. Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699. Kitanaka, J., et al. 1993. J. Neurochem. 60, 704. Wang, X., et al. 1993. Biochem. J. 290, 249. Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219. Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.

References

Berry, G.T., et al. 1994. Pediat. Res. 35, 141.
Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410.
Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699.
Kitanaka, J., et al. 1993. J. Neurochem. 60, 704.
Wang, X., et al. 1993. Biochem. J. 290, 249.
Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219.
Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.

Product Information
CAS number	60-82-2
ATP Competitive	N
Form	White solid
Hill Formula	C₁₅H₁₄O₅
Chemical formula	C₁₅H₁₄O₅
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PKC
Primary Target IC<sub>50</sub>	20-50 µM against protein kinase C
Purity	≥97% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
524488-200MGCN	04055977270990

Documentation

Phloretin - CAS 60-82-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Phloretin - CAS 60-82-2 - Calbiochem 分析证书

标题	批号
524488	输入批号

参考

参考信息概述
Berry, G.T., et al. 1994. Pediat. Res. 35, 141. Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167. Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410. Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699. Kitanaka, J., et al. 1993. J. Neurochem. 60, 704. Wang, X., et al. 1993. Biochem. J. 290, 249. Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219. Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	26-January-2012 JSW
Synonyms	2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone
Description	A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM). Activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca²⁺ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F_2α receptors linked to phospholipase C in astrocytes.
Form	White solid
CAS number	60-82-2
Chemical formula	C₁₅H₁₄O₅
Structure formula
Purity	≥97% by TLC
Solubility	Acetone, ethanol, or methanol
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.
Toxicity	Irritant
Merck USA index	14, 7326
References	Berry, G.T., et al. 1994. Pediat. Res. 35, 141. Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167. Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410. Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699. Kitanaka, J., et al. 1993. J. Neurochem. 60, 704. Wang, X., et al. 1993. Biochem. J. 290, 249. Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219. Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors

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