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530746 Sigma-AldrichPeroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem

A cell-permeable nematicidal compound that covalently binds to the peroxidatic cysteine of peroxiredoxin II in T. gondii and irreversibly blocks its hyperperoxidation activity (IC₅₀ = 23 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

同义词: 2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor

Primary Target: Peroxiredoxin

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
18080-67-6	C₁₀H₈Br₂N₂O₂

价格及供货情况

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Description
Overview	A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC₅₀ = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	530746
Brand Family	Calbiochem®
Synonyms	2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor

References
References	Nguyen, J.B., et al. 2013. Chem. Biol. 20, 991. Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040. Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.

Product Information
CAS number	18080-67-6
Form	Yelllowish brown solid
Hill Formula	C₁₀H₈Br₂N₂O₂
Chemical formula	C₁₀H₈Br₂N₂O₂
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	Peroxiredoxin
Primary Target IC<sub>50</sub>	23 µM for blocking TgPrxII hyperperoxidation activity
Purity	≥95% by NMR

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.30746.0001	04055977242942

Documentation

Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Nguyen, J.B., et al. 2013. Chem. Biol. 20, 991. Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040. Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	20-June-2014 JSW
Synonyms	2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
Description	A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC₅₀ = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.
Form	Yelllowish brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	18080-67-6
Chemical formula	C₁₀H₈Br₂N₂O₂
Purity	≥95% by NMR
Solubility	DMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
Storage	Protect from moisture Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
Toxicity	Standard Handling
References	Nguyen, J.B., et al. 2013. Chem. Biol. 20, 991. Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040. Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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