516485 Sigma-AldrichPepstatin A Methyl Ester - Calbiochem
A cell-permeable methyl ester derivative of Pepstatin A that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase.
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同义词: Isovaleryl-V V-Sta-A-Sta-OCH₃, PME
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概述
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重要规格表
| Empirical Formula |
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| C₃₅H₆₅N₅O₉ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
|---|---|---|---|---|---|---|
| 516485-1MGCN |
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塑胶安瓿;塑胶针药瓶 | 1 mg |
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| Description | |
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| Overview | A cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516481) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (Kis = 150 nM, Kii = 320 nM in solubilized human γ-secretase at 20°C; Kis is the inhibition constant for inhibitor binding to the free enzyme and Kii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex). Sta = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid. |
| Catalogue Number | 516485 |
| Brand Family | Calbiochem® |
| Synonyms | Isovaleryl-V V-Sta-A-Sta-OCH₃, PME |
| References | |
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| References | Tian, G., et al. 2002. J. Biol. Chem. 277, 31499. Zhang, L., et al. 2001. Biochemistry 40, 5049. Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914. |
| Product Information | |
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| ATP Competitive | N |
| Form | Lyophilized |
| Hill Formula | C₃₅H₆₅N₅O₉ |
| Chemical formula | C₃₅H₆₅N₅O₉ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | γ-secretase |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 516485-1MGCN | 07790788056308 |
Documentation
Pepstatin A Methyl Ester - Calbiochem MSDS
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Pepstatin A Methyl Ester - Calbiochem 分析证书
| 标题 | 批号 |
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| 516485 |
参考
| 参考信息概述 |
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| Tian, G., et al. 2002. J. Biol. Chem. 277, 31499. Zhang, L., et al. 2001. Biochemistry 40, 5049. Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914. |