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512732 Sigma-AldrichParthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem

A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
20554-84-1	C₁₅H₂₀O₃

价格及供货情况

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Description
Overview	A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
Catalogue Number	512732
Brand Family	Calbiochem®

References
References	Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375. Bork, P.M., et al. 1997. FEBS Lett. 402, 85. Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810. Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737. Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.

Product Information
CAS number	20554-84-1
ATP Competitive	N
Form	White solid
Hill Formula	C₁₅H₂₀O₃
Chemical formula	C₁₅H₂₀O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	LY4220000

Safety Information
R Phrase	R: 20/21/22-40-42/43 Harmful by inhalation, in contact with skin and if swallowed. Limited evidence of a carcinogenic effect. May cause sensitization by inhalation and skin contact.
S Phrase	S: 22-36 Do not breathe dust. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful & Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
512732-50MGCN	04055977272079

Documentation

Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem 分析证书

标题	批号
512732	输入批号

参考

参考信息概述
Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375. Bork, P.M., et al. 1997. FEBS Lett. 402, 85. Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810. Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737. Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-August-2021 JSW
Description	A sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
Form	White solid
CAS number	20554-84-1
RTECS	LY4220000
Chemical formula	C₁₅H₂₀O₃
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (100 mg/ml) or ethanol (20 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful & Carcinogenic / Teratogenic
References	Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375. Bork, P.M., et al. 1997. FEBS Lett. 402, 85. Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810. Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737. Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

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