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529573 Sigma-AldrichPP2 - CAS 172889-27-9 - Calbiochem

PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively).

PP2 - CAS 172889-27-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
技术信息
数据表
Data Sheet
Citations
Posters

同义词: AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine

Primary Target: p56^lck

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
172889-27-9	C₁₅H₁₆ClN₅

价格及供货情况

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Description
Overview	A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56^lck (IC₅₀ = 4 nM), p59^fynT (IC₅₀ = 5 nM), Hck (IC₅₀ = 5 nM), and Src (IC₅₀ = 100 nM). Does not significantly affect the activity of EGFR kinase (IC₅₀ = 480 nM), JAK2 (IC₅₀ > 50 µM), or ZAP-70 (IC₅₀ >100 µM). Inhibits the activation of focal adhesion kinase and its phosphorylation at Tyr⁵⁷⁷. Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC₅₀ = 600 nM). A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529576) in DMSO also available.
Catalogue Number	529573
Brand Family	Calbiochem®
Synonyms	AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine

References
References	Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

Product Information
CAS number	172889-27-9
ATP Competitive	Y
Form	Off-white solid
Hill Formula	C₁₅H₁₆ClN₅
Chemical formula	C₁₅H₁₆ClN₅
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	p56^lck
Primary Target IC<sub>50</sub>	4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck, and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
529573-1MGCN	07790788051198
529573-5MGCN	04055977269802

Documentation

PP2 - CAS 172889-27-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

PP2 - CAS 172889-27-9 - Calbiochem 分析证书

标题	批号
529573	输入批号

参考

参考信息概述
Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

小册子

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技术信息

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引用

标题

Dance, M., et al. 2006. Journal of Biological Chemistry 281, 23285.

Fukumoto, S., et al. 2006. Journal of Biological Chemistry 281, 5008.

Heiss, E., et al. 2006. Blood 108, 1542.

Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.

Olivera, A., et al. 2006. Journal of Biological Chemistry 281, 2515.

Rayala, S.K. et al. 2006. Journal of Biological Chemistry 281, 4395.

Ellen J. Tisdale and Cristina R. Artalejo. 2006. Journal of Biological Chemistry 281, 8436.

Meyn, M.A., et al. 2005. Molecular Pharmacology 68, 1320.

Summy, J.M., et al. 2005. Molecular Cancer Therapeutics 4, 1900.

Trevino, J.G., et al. 2005. Cancer Research 65, 7214.

Liao, X., et al. 2003. Endocrinology 144, 1656.

Cross, M.J., et al. 2002. Molecular Biology of the Cell 13, 2881.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-January-2010 RFH
Synonyms	AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
Description	A potent, reversible, ATP-competitive, and selective inhibitor of the src family of tyrosine kinases that is similar to PP1. Selectively inhibits p56^lck (IC₅₀ = 4 nM), p59^fynT (IC₅₀ = 5 nM), Hck (IC₅₀ = 5 nM), and Src (IC₅₀ = 100 nM) compared to other tyrosine kinases, such as EGF-R (IC₅₀ = 480 nM), JAK2 (IC₅₀ >50 µM) or ZAP-70 (IC₅₀ >100 µM). Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC₅₀ = 600 nM).
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	172889-27-9
Chemical formula	C₁₅H₁₆ClN₅
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (20 mg/ml). Further dilute with aqueous buffers just prior to use.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity	Standard Handling
References	Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.
Citation	Dance, M., et al. 2006. Journal of Biological Chemistry 281, 23285. Fukumoto, S., et al. 2006. Journal of Biological Chemistry 281, 5008. Heiss, E., et al. 2006. Blood 108, 1542. Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346. Olivera, A., et al. 2006. Journal of Biological Chemistry 281, 2515. Rayala, S.K. et al. 2006. Journal of Biological Chemistry 281, 4395. Ellen J. Tisdale and Cristina R. Artalejo. 2006. Journal of Biological Chemistry 281, 8436. Meyn, M.A., et al. 2005. Molecular Pharmacology 68, 1320. Summy, J.M., et al. 2005. Molecular Cancer Therapeutics 4, 1900. Trevino, J.G., et al. 2005. Cancer Research 65, 7214. Liao, X., et al. 2003. Endocrinology 144, 1656. Cross, M.J., et al. 2002. Molecular Biology of the Cell 13, 2881.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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