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528245 Sigma-AldrichPLD Inhibitor, FIPI - CAS 939055-18-2 - Calbiochem

The PLD Inhibitor, FIPI controls the biological activity of PLD. This small molecule/inhibitor is primarily used for Membrane applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Compound 4k, PLD Inhibitor I

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
939055-18-2	C₂₃H₂₄FN₅O₂

价格及供货情况

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Description
Overview	A cell-permeable, PLD1/2 inhibitor (IC₅₀ = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC₅₀ = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.
Catalogue Number	528245
Brand Family	Calbiochem®
Synonyms	Compound 4k, PLD Inhibitor I

References
References	Su, W., et al. 2009. Mol Pharmacol 75, 437. Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.

Product Information
CAS number	939055-18-2
Form	Off-white powder
Hill Formula	C₂₃H₂₄FN₅O₂
Chemical formula	C₂₃H₂₄FN₅O₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
528245-5MGCN	04055977196559

Documentation

PLD Inhibitor, FIPI - CAS 939055-18-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

PLD Inhibitor, FIPI - CAS 939055-18-2 - Calbiochem 分析证书

标题	批号
528245	输入批号

参考

参考信息概述
Su, W., et al. 2009. Mol Pharmacol 75, 437. Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-August-2012 JSW
Synonyms	Compound 4k, PLD Inhibitor I
Description	A cell-permeable, PLD1/2 inhibitor (IC₅₀ = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC₅₀ = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.
Form	Off-white powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	939055-18-2
Chemical formula	C₂₃H₂₄FN₅O₂
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Su, W., et al. 2009. Mol Pharmacol 75, 437. Monovich, L., et al. 2007. Bioorg Med Chem 17, 2310.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Phospholipase Inhibitors

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