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550602 Sigma-AldrichPKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem

PKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Pyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1186654-00-1	C₁₈H₁₈F₂N₂O₆S₂

价格及供货情况

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Description
Overview	A cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC₅₀ = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
Catalogue Number	550602
Brand Family	Calbiochem®
Synonyms	Pyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine

References
References	Anastasiou, D., et al. 2011. Science 334, 1278. Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.

Product Information
CAS number	1186654-00-1
Form	White powder
Hill Formula	C₁₈H₁₈F₂N₂O₆S₂
Chemical formula	C₁₈H₁₈F₂N₂O₆S₂
Structure formula Image
Quality Level	MQ100

Applications
Application	PKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
550602-10MGCN	04055977268874

Documentation

PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem 分析证书

标题	批号
550602	输入批号

参考

参考信息概述
Anastasiou, D., et al. 2011. Science 334, 1278. Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-October-2012 JSW
Synonyms	Pyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine
Description	A cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC₅₀ = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
Form	White powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1186654-00-1
Chemical formula	C₁₈H₁₈F₂N₂O₆S₂
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Anastasiou, D., et al. 2011. Science 334, 1278. Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Kinases Activators

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