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116805 Sigma-AldrichPKA Inhibitor 5-24 - CAS 99534-03-9 - Calbiochem

The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: Protein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV

Primary Target: PKA

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
99534-03-9	C₉₄H₁₄₈N₃₂O₃₁

价格及供货情况

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Description
Overview	A potent synthetic peptide that is a competitive inhibitor of protein kinase A (K_i = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate.
Catalogue Number	116805
Brand Family	Calbiochem®
Synonyms	Protein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV

References
References	Knighton, D.R., et al. 1991. Science 253, 525. Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989. Rusine, T., et al. 1986. J. Cell Biol. 102, 1630. Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.

Product Information
CAS number	99534-03-9
ATP Competitive	N
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.
Hill Formula	C₉₄H₁₄₈N₃₂O₃₁
Chemical formula	C₉₄H₁₄₈N₃₂O₃₁
Hygroscopic	Hygroscopic
Reversible	N
Sold on the basis of peptide content	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	PKA
Primary Target K<sub>i</sub>	2.3 nM for protein kinase A
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Content	Y
Peptide Sequence	H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
116805-500UGCN	04055977208214

Documentation

PKA Inhibitor 5-24 - CAS 99534-03-9 - Calbiochem 分析证书

标题	批号
116805	输入批号

参考

参考信息概述
Knighton, D.R., et al. 1991. Science 253, 525. Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989. Rusine, T., et al. 1986. J. Cell Biol. 102, 1630. Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-April-2008 RFH
Synonyms	Protein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
Description	Peptide corresponding to the active site on the skeletal muscle inhibitor protein. Competitive inhibitor of protein kinase A (K_i = 2.3 nM).
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.
CAS number	99534-03-9
Chemical formula	C₉₄H₁₄₈N₃₂O₃₁
Peptide Sequence	H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
Purity	≥95% by HPLC
Solubility	H₂O (1 mg/ml). Sonication or the addition of a few drops of dilute acid (10 mM HCl) may be necessary to achieve complete solubilization.
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity	Standard Handling
References	Knighton, D.R., et al. 1991. Science 253, 525. Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989. Rusine, T., et al. 1986. J. Cell Biol. 102, 1630. Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors

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