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528112 Sigma-AldrichPI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem

The PI 3-Kγ/CKII Inhibitor, also referenced under CAS 1138220-19-5, controls the biological activity of PI 3-Kγ/CKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: (5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, AS-252424, PI 3-K Inhibitor XII

Primary Target: PI 3-Kγ/CKII

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1138220-19-5	C₁₄H₈FNO₄S

价格及供货情况

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Description
Overview	A cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC₅₀ = 20 nM). It inhibits other PI 3-K isotypes (IC₅₀ = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC₅₀ >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
Catalogue Number	528112
Brand Family	Calbiochem®
Synonyms	(5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, AS-252424, PI 3-K Inhibitor XII

References
References	Pomel, V., et al. 2006. J. Med. Chem. 49, 3857.

Product Information
CAS number	1138220-19-5
ATP Competitive	Y
Form	Yellow solid
Hill Formula	C₁₄H₈FNO₄S
Chemical formula	C₁₄H₈FNO₄S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PI 3-Kγ/CKII
Primary Target IC<sub>50</sub>	20 nM against PI 3-Kγ and CKII
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
528112-5MGCN	04055977270532

Documentation

PI 3-Kγ/CKII Inhibitor - CAS 1138220-19-5 - Calbiochem 分析证书

标题	批号
528112	输入批号

参考

参考信息概述
Pomel, V., et al. 2006. J. Med. Chem. 49, 3857.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	18-April-2011 RFH
Synonyms	(5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, AS-252424, PI 3-K Inhibitor XII
Description	A cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC₅₀ = 20 nM). It inhibits other PI 3-K isotypes (IC₅₀ = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC₅₀ >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1138220-19-5
Chemical formula	C₁₄H₈FNO₄S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (20 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Pomel, V., et al. 2006. J. Med. Chem. 49, 3857.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Phosphatidylinositol 3-Kinase (PI 3-kinase) Inhibitors

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