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528100 Sigma-AldrichPI-103 - CAS 371935-74-9 - Calbiochem

A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR.

PI-103 - CAS 371935-74-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Posters

同义词: 3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V

Primary Target: DNA-PK, PI3-K, and mTOR

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
371935-74-9	C₁₉H₁₆N₄O₃

价格及供货情况

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Description
Overview	A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC₅₀ = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC₅₀ = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. A 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528101) in DMSO is also available.
Catalogue Number	528100
Brand Family	Calbiochem®
Synonyms	3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V

References
References	Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840. Fan, Q.W., et al. 2006. Cancer Cell 9, 341. Knight, Z.A., et al. 2006. Cell 125, 733.

Product Information
CAS number	371935-74-9
ATP Competitive	Y
Form	White solid
Hill Formula	C₁₉H₁₆N₄O₃
Chemical formula	C₁₉H₁₆N₄O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	DNA-PK, PI3-K, and mTOR
Primary Target IC<sub>50</sub>	2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110delta;, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
528100-1MGCN	04055977270457
528100-5MGCN	04055977270464

Documentation

PI-103 - CAS 371935-74-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

PI-103 - CAS 371935-74-9 - Calbiochem 分析证书

标题	批号
528100	输入批号

参考

参考信息概述
Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840. Fan, Q.W., et al. 2006. Cancer Cell 9, 341. Knight, Z.A., et al. 2006. Cell 125, 733.

海报

标题
Human Kinome & InhibitorSelect™ Libraries

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-October-2010 RFH
Synonyms	3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V
Description	A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC₅₀ = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC₅₀ = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	371935-74-9
Chemical formula	C₁₉H₁₆N₄O₃
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (5 mg/ml). Slight warming may be required for complete solubilization.
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840. Fan, Q.W., et al. 2006. Cancer Cell 9, 341. Knight, Z.A., et al. 2006. Cell 125, 733.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Phosphatidylinositol 3-Kinase (PI 3-kinase) Inhibitors

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