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521234 Sigma-AldrichPDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem

The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-Nʹ-(2-methylbenzoyl)thiourea, Ki11502

Primary Target: PDGFR

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
347155-76-4	C₂₆H₂₃N₃O₄S • 3H₂O

价格及供货情况

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Description
Overview	A cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC₅₀ = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC₅₀ = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.).
Catalogue Number	521234
Brand Family	Calbiochem®
Synonyms	N-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-Nʹ-(2-methylbenzoyl)thiourea, Ki11502

References
References	Getachew, R., et al. 2009. Eur. J. Pharmacol.<→i> In press. Nishioka, C., et al. 2008. Blood 111, 5086. Furuta, T., et al. 2006. J. Med. Chem. 49, 2186.

Product Information
CAS number	347155-76-4
ATP Competitive	Y
Form	Off-white solid
Hill Formula	C₂₆H₂₃N₃O₄S • 3H₂O
Chemical formula	C₂₆H₂₃N₃O₄S • 3H₂O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PDGFR
Primary Target IC<sub>50</sub>	4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Toxic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
521234-1MGCN	04055977271386

Documentation

PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem 分析证书

标题	批号
521234	输入批号

参考

参考信息概述
Getachew, R., et al. 2009. Eur. J. Pharmacol.<→i> In press. Nishioka, C., et al. 2008. Blood 111, 5086. Furuta, T., et al. 2006. J. Med. Chem. 49, 2186.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-November-2009 RFH
Synonyms	N-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-Nʹ-(2-methylbenzoyl)thiourea, Ki11502
Description	A cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC₅₀ = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC₅₀ = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.).
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	347155-76-4
Chemical formula	C₂₆H₂₃N₃O₄S • 3H₂O
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (25 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Toxic
References	Getachew, R., et al. 2009. Eur. J. Pharmacol.<→i> In press. Nishioka, C., et al. 2008. Blood 111, 5086. Furuta, T., et al. 2006. J. Med. Chem. 49, 2186.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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