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513030 Sigma-AldrichPD 169316 - CAS 152121-53-4 - Calbiochem

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

PD 169316 - CAS 152121-53-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole

Primary Target: p38 MAP kinase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
152121-53-4	C₂₀H₁₃FN₄O₂

价格及供货情况

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Description
Overview	A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
Catalogue Number	513030
Brand Family	Calbiochem®
Synonyms	4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole

References
References	Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

Product Information
CAS number	152121-53-4
ATP Competitive	Y
Form	Orange-yellow solid
Hill Formula	C₂₀H₁₃FN₄O₂
Chemical formula	C₂₀H₁₃FN₄O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	p38 MAP kinase
Primary Target IC<sub>50</sub>	89 nM against p38 MAP kinase
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
513030-1MGCN	04055977198621

Documentation

PD 169316 - CAS 152121-53-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

PD 169316 - CAS 152121-53-4 - Calbiochem 分析证书

标题	批号
513030	输入批号

参考

参考信息概述
Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-January-2010 RFH
Synonyms	4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
Description	A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
Form	Orange-yellow solid
CAS number	152121-53-4
Chemical formula	C₂₀H₁₃FN₄O₂
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity	Standard Handling
References	Nath, R., et al. 2001. Cell Mol. Biol. Lett. 6, 173. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

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