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14-683 PAK3 Protein, active, 10 µg

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14-683
10 µg  
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      概述

      Replacement Information
      Description
      Catalogue Number14-683
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPAK3 Protein, active, 10 µg
      OverviewC-terminal 6His-tagged, recombinant, human full length, PAK3.

      mitosis
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, C-terminal 6His-tagged, recombinant, human full length, PAK3. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourcePAK3 expressed by baculovirus in Sf21 cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryPAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
      Gene Symbol
      • PAK3
      • oligophrenin-3
      • CDKN1A
      • OPHN3
      • PAK3beta
      • PAK-3
      • Beta-PAK
      • OTTHUMP00000062894
      • Oligophrenin-3
      • hPAK3
      • MRX47
      • MRX30
      • bPAK
      Protein TargetPAK3
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O75914 # Key regulator of synapse formation and plasticity in the hippocampus (By similarity).
      COFACTOR: Magnesium (By similarity).
      SIZE: 559 amino acids; 62310 Da
      SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.
      TISSUE SPECIFICITY: Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
      PTM: Autophosphorylated when activated by CDC42/p21.
      DISEASE: SwissProt: O75914 # Defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X- linked mental retardation type 47 (MRX47). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs.
      SIMILARITY: SwissProt: O75914 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
      Molecular Weight63.2kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of PAKtide (RRRLSFAEPG).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      14-683 04053252673153

      Documentation

      PAK3 Protein, active, 10 µg MSDS

      职位

      物料安全数据表 (MSDS) 

      PAK3 Protein, active, 10 µg 分析证书

      标题批号
      PAK3, active - 31068U-C 31068U-C
      PAK3, active - D12SP012NA D12SP012NA
      PAK3, active - D13AP006NA D13AP006NA
      PAK3, active - D13BP002NA D13BP002NA

      参考

      参考概述公共医疗ID
      Rho proteins, mental retardation and the neurobiological basis of intelligence.
      van Galen, Elly J M and Ramakers, Ger J A
      Prog. Brain Res., 147: 295-317 (2005)  2005

      显示摘要
      15581714 15581714
      Rho proteins, mental retardation and the cellular basis of cognition.
      Ramakers, Ger J A
      Trends Neurosci., 25: 191-9 (2002)  2002

      显示摘要
      11998687 11998687
      p21-activated kinases: three more join the Pak.
      Jaffer, Zahara M and Chernoff, Jonathan
      Int. J. Biochem. Cell Biol., 34: 713-7 (2002)  2002

      显示摘要
      11950587 11950587
      Cytostatic p21 G protein-activated protein kinase gamma-PAK.
      Roig, J and Traugh, J A
      Vitam. Horm., 62: 167-98 (2001)  2001

      显示摘要
      11345898 11345898