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496915 Sigma-AldrichOridonin, R. rubescens - CAS 28957-04-2 - Calbiochem

A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative and antiangiogenic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: NF-κB transcriptional activity

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
28957-04-2	C₂₀H₂₈O₆

价格及供货情况

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Description
Overview	A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED₅₀ = ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC₅₀ = ~ 5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.
Catalogue Number	496915
Brand Family	Calbiochem®

References
References	Ikezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578. Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.

Product Information
CAS number	28957-04-2
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₂₀H₂₈O₆
Chemical formula	C₂₀H₂₈O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	NF-κB transcriptional activity
Primary Target IC<sub>50</sub>	5 µg/ml inhibiting p65 NF-κB transcriptional activity in MT-1 cells
Purity	≥93% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	NZ8177000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
496915-5MGCN	04055977199871

Documentation

Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem 分析证书

标题	批号
496915	输入批号

参考

参考信息概述
Ikezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578. Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-January-2017 JSW
Description	A cell-permeable inhibitor of NF-κB activity that displays antiproliferative (ED₅₀ ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis, and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages. Also inhibits p65 NF-κB transcriptional activity (IC₅₀ ~5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	28957-04-2
RTECS	NZ8177000
Chemical formula	C₂₀H₂₈O₆
Structure formula
Purity	≥93% by HPLC
Solubility	DMSO (10 mg/ml). Use only fresh DMSO for reconstitution.
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Ikezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578. Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

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