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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

499635 Sigma-AldrichOSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem

The OSC Inhibitor, Ro 48-8071, also referenced under CAS 189197-69-1, controls the biological activity of 2,3-oxidosqualene:lanosterol cyclase activity (OSC).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
189197-69-1	C₂₃H₂₇BrFNO₂• C₄H₄O₄

价格及供货情况

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Description
Overview	An orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC₅₀ ~ 6.5 nM against mammalian) and reduces cholesterol synthesis (IC₅₀ ~ 1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC₅₀ ~ 10 µM).
Catalogue Number	499635
Brand Family	Calbiochem®
Synonyms	4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate

References
References	Thoma, R., et al. 2004. Nature 432, 118. Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439. Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.

Product Information
CAS number	189197-69-1
Form	Off-white solid
Hill Formula	C₂₃H₂₇BrFNO₂• C₄H₄O₄
Chemical formula	C₂₃H₂₇BrFNO₂• C₄H₄O₄
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Regulatory Review
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
499635-10MGCN	04055977199284

Documentation

OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem 分析证书

标题	批号
499635	输入批号

参考

参考信息概述
Thoma, R., et al. 2004. Nature 432, 118. Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439. Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-December-2018 JSW
Synonyms	4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate
Description	An orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC₅₀ ~6.5 nM against mammalian) and reduces cholesterol synthesis (IC₅₀ ~1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC₅₀ ~10 µM).
Form	Off-white solid
CAS number	189197-69-1
Chemical formula	C₂₃H₂₇BrFNO₂• C₄H₄O₄
Structure formula
Purity	≥95% by HPLC
Solubility	H₂O (5 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Regulatory Review
References	Thoma, R., et al. 2004. Nature 432, 118. Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439. Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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