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495320 Sigma-AldrichODQ - CAS 41443-28-1 - Calbiochem

A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM).

ODQ - CAS 41443-28-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

Primary Target: (NO)-sensitive guanylyl cyclase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
41443-28-1	C₉H₅N₃O₂

价格及供货情况

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Description
Overview	A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
Catalogue Number	495320
Brand Family	Calbiochem®
Synonyms	1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

References
References	Wang, D., et al. 1998. J. Biol. Chem. 273, 33027. Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527. Brunner, F., et al. 1995. FEBS Lett. 376, 262. Garthwaite, J., et al. 1995. Mol. Pharmacol. 48, 184.

Product Information
CAS number	41443-28-1
ATP Competitive	N
Form	Light yellow powder
Hill Formula	C₉H₅N₃O₂
Chemical formula	C₉H₅N₃O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	(NO)-sensitive guanylyl cyclase
Primary Target IC<sub>50</sub>	20 nM against nitric oxide (NO)-sensitive guanylyl cyclase
Purity	≥98% by TLC and HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
495320-10MGCN	04055977273045

Documentation

ODQ - CAS 41443-28-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

ODQ - CAS 41443-28-1 - Calbiochem 分析证书

标题	批号
495320	输入批号

参考

参考信息概述
Wang, D., et al. 1998. J. Biol. Chem. 273, 33027. Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527. Brunner, F., et al. 1995. FEBS Lett. 376, 262. Garthwaite, J., et al. 1995. Mol. Pharmacol. 48, 184.

小册子

标题
Pathways and Biomarkers of Oxidative Stress

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-August-2008 RFH
Synonyms	1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Description	A potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ fails to inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
Form	Light yellow powder
CAS number	41443-28-1
Chemical formula	C₉H₅N₃O₂
Structure formula
Purity	≥98% by TLC and HPLC
Solubility	DMSO (25 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Wang, D., et al. 1998. J. Biol. Chem. 273, 33027. Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527. Brunner, F., et al. 1995. FEBS Lett. 376, 262. Garthwaite, J., et al. 1995. Mol. Pharmacol. 48, 184.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Guanylate Cyclase Inhibitors

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