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482200 Nimodipine - CAS 66085-59-4 - Calbiochem

An L-type Ca2+ channel blocker.

Nimodipine - CAS 66085-59-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester

Primary Target: L-type Ca2+ channel blocker
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482200
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
66085-59-4C₂₁H₂₆N₂O₇

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
482200-25MGCN
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      		 塑胶安瓿;塑胶针药瓶 25 mg
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      Description
      OverviewAn L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Also reported to block TNF-α and LPS-induced iNOS activity (IC50 = 36 pM) in mouse astroglial cells.
      Catalogue Number482200
      Brand Family Calbiochem®
      Synonyms1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester
      References
      ReferencesZhu, D., et al. 1999. Life. Sci. 65, PL 221.
      Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
      Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
      Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
      Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.
      Product Information
      CAS number66085-59-4
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₁H₂₆N₂O₇
      Chemical formulaC₂₁H₂₆N₂O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetL-type Ca2+ channel blocker
      Primary Target IC<sub>50</sub>36 pM blocking TNF-α and LPS-induced iNOS activity in mouse astroglial cells
      Purity>98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUS7975500
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      482200-25MGCN 04055977183498

      Documentation

      Nimodipine - CAS 66085-59-4 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Nimodipine - CAS 66085-59-4 - Calbiochem 分析证书

      标题批号
      482200

      参考

      参考信息概述
      Zhu, D., et al. 1999. Life. Sci. 65, PL 221.
      Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
      Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
      Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
      Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-July-2023 JSW
      Synonyms1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester
      DescriptionAn L-type Ca2+ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats.
      FormYellow solid
      CAS number66085-59-4
      RTECSUS7975500
      Chemical formulaC₂₁H₂₆N₂O₇
      Structure formulaStructure formula
      Purity>98% by HPLC
      SolubilityDMSO (25 mg/ml) or methanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 6551
      ReferencesZhu, D., et al. 1999. Life. Sci. 65, PL 221.
      Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
      Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111, 887.
      Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
      Kappelle, A.C., et al. 1993. Br. J. Pharmacol. 108, 780.