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481984 Sigma-AldrichNifuroxazide - CAS 965-52-6 - Calbiochem

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity.

Nifuroxazide - CAS 965-52-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
965-52-6	C₁₂H₉N₃O₅

价格及供货情况

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Description
Overview	A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC₅₀ = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-_κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC₅₀ = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.
Catalogue Number	481984
Brand Family	Calbiochem®
Synonyms	5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone

References
References	Nelson, E.A., et al. 2008. Blood 112, 5095.

Product Information
CAS number	965-52-6
Form	Bright yellow solid
Hill Formula	C₁₂H₉N₃O₅
Chemical formula	C₁₂H₉N₃O₅
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
481984-500MGCN	04055977183450

Documentation

Nifuroxazide - CAS 965-52-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Nifuroxazide - CAS 965-52-6 - Calbiochem 分析证书

标题	批号
481984	输入批号

参考

参考信息概述
Nelson, E.A., et al. 2008. Blood 112, 5095.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-April-2009 RFH
Synonyms	5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone
Description	A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC₅₀ = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-_κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC₅₀ = 10 µM against tyr⁷⁰⁵ of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser⁷²⁷ phosphorylation of STAT3.
Form	Bright yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	965-52-6
Chemical formula	C₁₂H₉N₃O₅
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Standard Handling
References	Nelson, E.A., et al. 2008. Blood 112, 5095.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > STAT Signaling Inhibitors

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