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A potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175. Cusack, B. et al. 1994. Psychopharmacol.114, 559.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
Form
White solid
CAS number
82752-99-6
Chemical formula
C₂₅H₃₂ClN₅O2·HCl
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO (25 mM) or Ethanol (10 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175. Cusack, B. et al. 1994. Psychopharmacol.114, 559.
