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504528 Sigma-AldrichNVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: NMDA Antagonist VII, NVP-AAM077, [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate, PEAQX tetrasodium hydrate

Primary Target: NMDA receptors

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
459836-30-7	C₁₇H₁₇BrN₃Na₄O₆P

价格及供货情况

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Description
Overview	A potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC₅₀ = 0.015 and 0.078 µM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy.
Catalogue Number	504528
Brand Family	Calbiochem®
Synonyms	NMDA Antagonist VII, NVP-AAM077, [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate, PEAQX tetrasodium hydrate

References
References	Frizelle. P., et al. 2006. Mol. Pharmacol. 70, 1022. Milton, A., et al. 2013. J. Neurosci. 33, 1109. Kochlamazashvili, G., et al. 2012. J. Neurosci. 32, 2263. Kocsis, B., et al. 2012. Sleep. 35, 1011.

Product Information
CAS number	459836-30-7
Form	White solid
Hill Formula	C₁₇H₁₇BrN₃Na₄O₆P
Chemical formula	C₁₇H₁₇BrN₃Na₄O₆P
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	NMDA receptors
Primary Target IC<sub>50</sub>	0.015 and 0.078 µM for NR2A and NR2B, respectively.
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.04528.0001	04055977263756

Documentation

NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem 分析证书

标题	批号
504528	输入批号

参考

参考信息概述
Frizelle. P., et al. 2006. Mol. Pharmacol. 70, 1022. Milton, A., et al. 2013. J. Neurosci. 33, 1109. Kochlamazashvili, G., et al. 2012. J. Neurosci. 32, 2263. Kocsis, B., et al. 2012. Sleep. 35, 1011.

小册子

标题
Pathways and Biomarkers of Glutamatergic Synapse Flyer

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-March-2015 JSW
Synonyms	NMDA Antagonist VII, NVP-AAM077, [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate, PEAQX tetrasodium hydrate
Description	A potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC₅₀ = 0.015 and 0.078 µM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy.
Form	White solid
CAS number	459836-30-7
Chemical formula	C₁₇H₁₇BrN₃Na₄O₆P
Structure formula
Purity	≥99% by HPLC
Solubility	H₂O (24 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Frizelle. P., et al. 2006. Mol. Pharmacol. 70, 1022. Milton, A., et al. 2013. J. Neurosci. 33, 1109. Kochlamazashvili, G., et al. 2012. J. Neurosci. 32, 2263. Kocsis, B., et al. 2012. Sleep. 35, 1011.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Antagonists > Glutamate Receptor Antagonists

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