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508509
Sigma-AldrichNS309 - CAS 18711-16-5 - Calbiochem
A potent activator of Ca2+ -activated K+ channels of SK and IK types, but not BK type channels. It is at least 1000 times more potent than 1-EBIO.
More>>A potent activator of Ca2+ -activated K+ channels of SK and IK types, but not BK type channels. It is at least 1000 times more potent than 1-EBIO. Less<<
NS309 - CAS 18711-16-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC50 = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Leurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol.377, 101. Morimura, K. et al. 2006. J. Pharmacol. Sci.100, 237. Strobaek, D. et al. 2004. Biochim. Biophys. Acta.1665, 1.
Leurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol.377, 101. Morimura, K. et al. 2006. J. Pharmacol. Sci.100, 237. Strobaek, D. et al. 2004. Biochim. Biophys. Acta.1665, 1.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC50 = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.
Form
Yellow solid
CAS number
18711-16-5
Chemical formula
C₈H₄Cl₂N₂O₂
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (100 mM)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Leurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol.377, 101. Morimura, K. et al. 2006. J. Pharmacol. Sci.100, 237. Strobaek, D. et al. 2004. Biochim. Biophys. Acta.1665, 1.
