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349254 Sigma-AldrichNS-398 - CAS 123653-11-2 - Calbiochem

A cell-permeable selective inhibitor of COX-2 in vitro.

NS-398 - CAS 123653-11-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide

Primary Target: COX-2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
123653-11-2	C₁₃H₁₈N₂O₅S

价格及供货情况

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Description
Overview	A cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC₅₀ = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.
Catalogue Number	349254
Brand Family	Calbiochem®
Synonyms	N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide

References
References	Ouellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247. Futaki, N., et al. 1994. Prostaglandins 47, 55. Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259. Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105. Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.

Product Information
CAS number	123653-11-2
ATP Competitive	N
Form	Pale yellow solid
Hill Formula	C₁₃H₁₈N₂O₅S
Chemical formula	C₁₃H₁₈N₂O₅S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	COX-2
Primary Target IC<sub>50</sub>	3.8 µM against COX-2
Purity	≥98% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
349254-5MGCN	04055977193213

Documentation

NS-398 - CAS 123653-11-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

NS-398 - CAS 123653-11-2 - Calbiochem 分析证书

标题	批号
349254	输入批号

参考

参考信息概述
Ouellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247. Futaki, N., et al. 1994. Prostaglandins 47, 55. Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259. Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105. Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	01-July-2008 RFH
Synonyms	N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
Description	A cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC₅₀ = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes.
Form	Pale yellow solid
CAS number	123653-11-2
Chemical formula	C₁₃H₁₈N₂O₅S
Structure formula
Purity	≥98% by TLC
Solubility	DMSO (20 mg/ml)
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity	Standard Handling
References	Ouellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247. Futaki, N., et al. 1994. Prostaglandins 47, 55. Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259. Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105. Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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