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492002 Sigma-AldrichNOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem

The NOX1 Inhibitor, ML171, also referenced under CAS 6631-94-3, controls the biological activity of NOX1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: NADPH Oxidase-1 Inhibitor, ML171, 2-APT, 2-acetylphenothiazine

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
6631-94-3	C₁₄H₁₁NOS

价格及供货情况

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Description
Overview	A highly selective, cell-permeable, and reversible 2-acetylphenothiazine that is shown to inhibit NADPH Oxidase-1 (Nox1) (IC₅₀ = 0.129 µM, and 0.25 µM) in human HT29 and HEK293 cell-based assays, respectively. Unlike most other currently used Nox inhibitors, it only has marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms (IC₅₀ = 5 µM, 3 µM and 5 µM for Nox2, Nox3, and Nox4, respectively) and xanthine oxidase, XO, (IC₅₀ = 5.5 µM) in HEK293 cell-based assays. It is also shown to block Nox1-dependent ROS generation in HEK293 cultures dose-dependently at concentrations up to ~ 100 nM; however, its inhibitory effect is reversed through over-expression of Nox1, thereby suggesting that this compound is highly selective for Nox1, with little effect against Nox2-dependent ROS generation (IC₅₀ > 10 µM). Qualitatively, it displays an inhibitory effect against SrcYF-induced ECM-degrading invadopodia formation in DLD1 Human Colon Cancer Cells. Note: this compound has been reported to interfere with peroxidase-dependent ROS-measuring assays and show no effect on PMA-induced respiratory burst of human granulocytes (Seredenina, T., et al).
Catalogue Number	492002
Brand Family	Calbiochem®
Synonyms	NADPH Oxidase-1 Inhibitor, ML171, 2-APT, 2-acetylphenothiazine

References
References	Seredenina, T., et al. 2015. Free Radic. Biol. Med. 239. Gianni, D., et al. 2010. ACS Chem. Biol. 5, 981.

Product Information
CAS number	6631-94-3
Form	Dark yellow-orange powder
Hill Formula	C₁₄H₁₁NOS
Chemical formula	C₁₄H₁₁NOS
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Regulatory Review
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
492002-10MGCN	04055977273465

Documentation

NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem 分析证书

标题	批号
492002	输入批号

参考

参考信息概述
Seredenina, T., et al. 2015. Free Radic. Biol. Med. 239. Gianni, D., et al. 2010. ACS Chem. Biol. 5, 981.

小册子

标题
Pathways and Biomarkers of Oxidative Stress

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-November-2020 JSW
Synonyms	NADPH Oxidase-1 Inhibitor, ML171, 2-APT, 2-acetylphenothiazine
Description	A highly selective, cell-permeable, and reversible 2-acetylphenothiazine that is shown to inhibit NADPH Oxidase-1 (Nox1) (IC₅₀ = 0.129 µM, and 0.25 µM) in human HT29 and HEK293 cell-based assays, respectively. Unlike most other currently used Nox inhibitors, it only has marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms (IC₅₀ = 5 µM, 3 µM and 5 µM for Nox2, Nox3, and Nox4, respectively) and xanthine oxidase, XO, (IC₅₀ = 5.5 µM) in HEK293 cell-based assays. It is also shown to block Nox1-dependent ROS generation in HEK293 cultures dose-dependently at concentrations up to ~100 nM; however, its inhibitory effect is reversed through over-expression of Nox1, thereby suggesting that this compound is highly selective for Nox1, with little effect against Nox2-dependent ROS generation (IC₅₀ > 10 µM). Qualitatively, it displays an inhibitory effect against SrcYF-induced ECM-degrading invadopodia formation in DLD1 Human Colon Cancer Cells. Note: this compound has been reported to interfere with peroxidase-dependent ROS-measuring assays and show no effect on PMA-induced respiratory burst of human granulocytes (Seredenina, T., et al).
Form	Dark yellow-orange powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	6631-94-3
Chemical formula	C₁₄H₁₁NOS
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Regulatory Review
References	Seredenina, T., et al. 2015. Free Radic. Biol. Med. 239. Gianni, D., et al. 2010. ACS Chem. Biol. 5, 981.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress

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