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532336 Sigma-AldrichNOX Inhibitor VIII, VAS3947 - CAS 869853-70-3 - Calbiochem

VAS3947, NOXi

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
小册子
技术信息
Data Sheet

同义词: 3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 2-((3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)oxazole, NADPH Oxidase Inhibitor VIII, VAS-3947

Primary Target: NADPH Oxidase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
869853-70-3	C₁₄H₁₀N₆OS

价格及供货情况

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Description
Overview	A cell-permeable triazolo-pyrimidine derivative of VAS2870 (Cat. No. 492000) that displays enhanced solubility and acts as a selective inhibitor NOX family of NADPH oxidase. Shown to inhibit NOX activity in CaCo-2 cells (expressing NOX 1, 2, 4, and 5; IC₅₀ = 12 µM), HL-60 cells (mainly expressing NOX2; IC₅₀ = 2 µM), and A7r5 cells (mainly expressing NOX3 and 4; IC₅₀ = 13 µM). Does not affect the activities of xanthine oxidase and endothelial nitric oxide synthase (eNOS) even at higher concentrations (~100 µM). Acts synergistically with Imatinib (Cat. No. 504595) to reduce the proliferation of chronic myeloid leukemia (CML) cells. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	532336
Brand Family	Calbiochem®
Synonyms	3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 2-((3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)oxazole, NADPH Oxidase Inhibitor VIII, VAS-3947

References
References	Sanchez-Sanchez, B., et al. 2014. Clin. Cancer Res. 20, 4014. Altenhofer, S., et al., 2012. Cell. Mol. Life Sci. 69, 2327. Wind, S., et al. 2010. Br. J. Pharmacol. 161, 885.

Product Information
CAS number	869853-70-3
Form	Light yellow solid
Hill Formula	C₁₄H₁₀N₆OS
Chemical formula	C₁₄H₁₀N₆OS
Quality Level	MQ100

Applications

Biological Information
Primary Target	NADPH Oxidase
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.32336.0001	04055977260069

Documentation

NOX Inhibitor VIII, VAS3947 - CAS 869853-70-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Sanchez-Sanchez, B., et al. 2014. Clin. Cancer Res. 20, 4014. Altenhofer, S., et al., 2012. Cell. Mol. Life Sci. 69, 2327. Wind, S., et al. 2010. Br. J. Pharmacol. 161, 885.

小册子

标题
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors
Pathways and Biomarkers of Oxidative Stress

技术信息

标题
White Paper: Further considerations of antibody validation and usage.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-December-2014 JSW
Synonyms	3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 2-((3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)oxazole, NADPH Oxidase Inhibitor VIII, VAS-3947
Description	A cell-permeable VAS2870 (Cat No. 492000) analogue that displays improved solubility and effectively blocks ROS production in DMSO-differentiated HL-60 cultures upon oxidative burst induction by PMA (IC₅₀ = 1 µM by Cytochrome C reduction & 2 µM by L012 chemiluminescence; Drug added 30 min prior to 100 nM PMA/500582 & 524400) via NADPH oxidases/NOX inhibition, while displaying no potency against eNOS or xanthine oxidase/XOD enzymatic activity in cell-free assays even at a high concentration of 100 µM. Reported to suppress the high ROS level in isolated thoracis aortas sections from spontaneously hypertensive rats (SHRs) in situ (by 66% with 10 µM) and synergize with Imatinib (Cat. No. 504595) against the proliferation of p210 Bcr-abl-expressing murine Boff 210 cultures. A commonly employed NOX inhibitor Apocynin (Cat. No. 178385), in comparison, is shown to interfere with L012-based assays and exhibit little potency against NOX-mediated ROS production in DMSO-differentiated HL-60 cultures (by Cytochrome C reduction) or in cell-free assays using A7r5 & CaCo-2 homogenates (IC₅₀ >1 mM), while another NOX inhibitor DPI (Cat. No. 300260) is shown to inhibit both eNOS & XOD activities.
Form	Light yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	869853-70-3
Chemical formula	C₁₄H₁₀N₆OS
Purity	≥98% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Sanchez-Sanchez, B., et al. 2014. Clin. Cancer Res. 20, 4014. Altenhofer, S., et al., 2012. Cell. Mol. Life Sci. 69, 2327. Wind, S., et al. 2010. Br. J. Pharmacol. 161, 885.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress

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