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538120 Sigma-AldrichNLRP3 Inhibitor, MCC950 - CAS 256373-96-3 - Calbiochem

A cell-potent, bioavailable NLRP3 inflammasome activation inhibitor. Effectively blocks caspase-1 & -11 activation, IL-1β processing and IL-1β & IL-6 secretion.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N-(1,2,3,5,6,7-Hexahydro-s-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide, Sodium, MCC-950, MCC950, Cytokine Release Inhibitory Drug 3, CRID 3, CP-456,773

Primary Target: NLRP3

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
256373-96-3	C₂₀H₂₃N₂O₅S·Na

价格及供货情况

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Description
Overview	A cell-permeable, bioavailable, non-toxic sulfonylurea derived compound that selectively interacts with NLRP3 inflammasome and prevents its activation in a reversible manner with no effect on NLRC4 and NLRP1. Dose-dependently reduces IL-1β production (IC₅₀ = 7.5 & 8.1 nM in LPS & ATP-treated BMDMs & HMDMs, respectively) with minimal effect on IL-1α & TNF-α. Specifically blocks NLRP3-dependent pyroptotic cell death by inhibiting caspase-1 &-11 activation, IL-1β processing and ASC oligomerization. Does neither block K⁺ efflux, Ca²⁺ flux or NLRP3-ASC interactions nor inhibit NLRC4, AIM2, TLR signaling or NLRP3 priming. Effectively suppresses T cell responses and IL-1β & IL-6 secretion, and reduces the severity of EAE and rescues neonatal lethality in a mouse model of CAPS (10 mg/kg, i.p., q.d. & 20 mg/kg, i.p., every other day, respectively). Displays attractive PK profile with desirable microsomal stability and minimal liability towards CYP450 isozymes (< 15% inhibition at 10 µM) & hERG (IC₅₀ > 30 µM). Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number	538120
Brand Family	Calbiochem®
Synonyms	N-(1,2,3,5,6,7-Hexahydro-s-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide, Sodium, MCC-950, MCC950, Cytokine Release Inhibitory Drug 3, CRID 3, CP-456,773
Description	NLRP3 Inhibitor, MCC950

References
References	Coll, R.C., et al. 2015. Nat. Med. 21, 248. Coll, R.C. and O'Neill, L.A.J. 2011. PLoS ONE. 6, e29539. Laliberte, R.E., et al. 2003. J. Biol. Chem. 278, 16567. Perregaux, D.G., et al. 2001. J. Pharmacol. Exp. Ther. 299, 187.

Product Information
CAS number	256373-96-3
Form	White powder
Formulation	Supplied as a sodium salt.
Hill Formula	C₂₀H₂₃N₂O₅S·Na
Chemical formula	C₂₀H₂₃N₂O₅S·Na
Hygroscopic	Hygroscopic
Reversible	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	NLRP3
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.38120.0001	04054839059308

Documentation

NLRP3 Inhibitor, MCC950 - CAS 256373-96-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

NLRP3 Inhibitor, MCC950 - CAS 256373-96-3 - Calbiochem 分析证书

标题	批号
538120	输入批号

参考

参考信息概述
Coll, R.C., et al. 2015. Nat. Med. 21, 248. Coll, R.C. and O'Neill, L.A.J. 2011. PLoS ONE. 6, e29539. Laliberte, R.E., et al. 2003. J. Biol. Chem. 278, 16567. Perregaux, D.G., et al. 2001. J. Pharmacol. Exp. Ther. 299, 187.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	25-June-2016 JSW
Synonyms	N-(1,2,3,5,6,7-Hexahydro-s-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide, Sodium, MCC-950, MCC950, Cytokine Release Inhibitory Drug 3, CRID 3, CP-456,773
Description	A cell-permeable, bioavailable, non-toxic sulfonylurea derived compound that selectively interacts with NLRP3 inflammasome and prevents its activation in a reversible manner with no effect on NLRC4 and NLRP1. Dose-dependently reduces IL-1β production (IC₅₀ = 7.5 & 8.1 nM in LPS & ATP-treated BMDMs & HMDMs, respectively) with minimal effect on IL-1α & TNF-α. Specifically blocks NLRP3-dependent pyroptotic cell death by inhibiting caspase-1 &-11 activation, IL-1β processing and ASC oligomerization. Does neither block K⁺ efflux, Ca²⁺ flux or NLRP3-ASC interactions nor inhibit NLRC4, AIM2, TLR signaling or NLRP3 priming. Effectively suppresses T cell responses and IL-1β & IL-6 secretion, and reduces the severity of EAE and rescues neonatal lethality in a mouse model of CAPS (10 mg/kg, i.p., q.d. & 20 mg/kg, i.p., every other day, respectively). Displays attractive PK profile with desirable microsomal stability and minimal liability towards CYP450 isozymes (< 15% inhibition at 10 µM) & hERG (IC₅₀ > 30 µM).
Form	White powder
Formulation	Supplied as a sodium salt.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	256373-96-3
Chemical formula	C₂₀H₂₃N₂O₅S·Na
Purity	≥97% by HPLC
Solubility	DMSO (50 mg/ml) or H₂O (1 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Coll, R.C., et al. 2015. Nat. Med. 21, 248. Coll, R.C. and O'Neill, L.A.J. 2011. PLoS ONE. 6, e29539. Laliberte, R.E., et al. 2003. J. Biol. Chem. 278, 16567. Perregaux, D.G., et al. 2001. J. Pharmacol. Exp. Ther. 299, 187.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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