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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

399250 Sigma-AldrichN^G-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem

Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: NOHA, AcOH

Primary Target: liver and macrophage arginase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
53598-01-9	C₆H₁₄N₄O₃ · CH₃CO₂H

价格及供货情况

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Description
Overview	Cell permeable. A key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. A potent inhibitor of liver and macrophage arginase (K_i = 150 µM).
Catalogue Number	399250
Brand Family	Calbiochem®
Synonyms	NOHA, AcOH

References
References	Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614. Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963. Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880. Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259. Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528. Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.

References

Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963.
Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880.
Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259.
Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528.
Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.

Product Information
CAS number	53598-01-9
Form	White solid
Hill Formula	C₆H₁₄N₄O₃ · CH₃CO₂H
Chemical formula	C₆H₁₄N₄O₃ · CH₃CO₂H
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	liver and macrophage arginase
Primary Target K<sub>i</sub>	150 µM
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
399250-5MGCN	04055977212556

Documentation

N^G-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

N^G-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem 分析证书

标题	批号
399250	输入批号

参考

参考信息概述
Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614. Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963. Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880. Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259. Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528. Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.

参考信息概述

小册子

标题
Pathways and Biomarkers of Oxidative Stress

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-October-2023 JSW
Synonyms	NOHA, AcOH
Description	Cell-permeable. A key intermediate product in the biosynthesis of nitric oxide from arginine by constitutive nitric oxide synthase (cNOS). Formed by the NADPH-dependent hydroxylation of L-arginine. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450, providing an alternative biosynthetic route for the production of nitric oxide. A potent inhibitor of liver and macrophage arginase (K_i = 150 µM).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	53598-01-9
Chemical formula	C₆H₁₄N₄O₃ · CH₃CO₂H
Structure formula
Purity	≥98% by HPLC
Solubility	H₂O (1 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614. Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963. Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880. Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259. Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528. Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Arginase Inhibitors

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399250 Sigma-AldrichN^G-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem

Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.

同义词: NOHA, AcOH

Recommended Products

概述

重要规格表

价格及供货情况

Documentation

N^G-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem MSDS

N^G-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem 分析证书

参考

小册子

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Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.

同义词: NOHA, AcOH

Recommended Products

重要规格表

价格及供货情况

NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem MSDS

NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem 分析证书

参考

小册子

种类

最近查看的内容

N^G-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem MSDS

N^G-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem 分析证书