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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

480450 Sigma-AldrichNFF-2 - Calbiochem

A quenched fluorescence substrate for MMPs.

NFF-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: MCA-RPKPYANvaWMK(DNP)-NH₂

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概述

Replacement Information

价格及供货情况

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Description
Overview	A quenched fluorescence substrate for MMPs. MMP-3 (stromelysin-1) hydrolyzes this substrate (k_cat/K_m = 5.9 x 10⁴ M^-1sec^-1) at a rate 60 times faster than the hydrolysis by MMP-1 (interstitial collagenase). NFF-2 shows little discrimination between MMP-3, MMP-2 (gelatinase-A; k_cat/K_m = 5 x 10⁴ M^-1s^-1), and MMP-9 (gelatinase-B; k_cat/K_m = 5.5 x 10⁴ M^-1s^-1).
Overview	Supplied as a trifluoroacetate salt.
Catalogue Number	480450
Brand Family	Calbiochem®
Synonyms	MCA-RPKPYANvaWMK(DNP)-NH₂

References
References	Nagase, H., et al. 1994. J. Biol. Chem. 269, 20952.

Product Information
ATP Competitive	N
Form	Lyophilized yellow solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₇₉H₁₀₅N₁₉O₁₉S
Chemical formula	C₇₉H₁₀₅N₁₉O₁₉S
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	Matrix Metalloproteinases (MMPs)
Primary Target IC<sub>50</sub>	kcat/Km = 5.9 x 104 M-1sec-1 as substrates for MMP-3 (stromelysin-1)
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N
Emission max.
Excitation max.
Peptide Sequence	MCA-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(DNP)-NH₂ (DNP = 2,4-dinitrophenyl; Nva = L-norvaline)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
480450-1MGCN	04055977201376

Documentation

NFF-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

NFF-2 - Calbiochem 分析证书

标题	批号
480450	输入批号

参考

参考信息概述
Nagase, H., et al. 1994. J. Biol. Chem. 269, 20952.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-August-2008 RFH
Synonyms	MCA-RPKPYANvaWMK(DNP)-NH₂
Description	A quenched fluorescent substrate for MMPs (excitation maximum: ~325 nm; emission maximum: ~393 nm). MMP-3 (stromelysin-1) hydrolyzes this substrate (k_cat/K_m = 59,400 M^-1s^-1) at a rate 60X faster than hydrolysis by MMP-1 (interstitial collagenase). NFF-2 shows little discrimination between MMP-3, MMP-2 (gelatinase-A; k_cat/K_m = 54,000 M^-1s^-1), and MMP-9 (gelatinase-B; k_cat/K_m = 55,300 M^-1s^-1).
Form	Lyophilized yellow solid
Formulation	Supplied as a trifluoroacetate salt.
Chemical formula	C₇₉H₁₀₅N₁₉O₁₉S
Peptide Sequence	MCA-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(DNP)-NH₂ (DNP = 2,4-dinitrophenyl; Nva = L-norvaline)
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from moisture Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Nagase, H., et al. 1994. J. Biol. Chem. 269, 20952.

种类

Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Protease Substrates

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